CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types

Bibliographic Details
Main Author: Barros, Leandro
Publication Date: 2023
Other Authors: Piontkivska, Daryna, Figueiredo-Campos, Patrícia, Fanczal, Júlia, Ribeiro, Sofia Pereira, Baptista, Marta, Ariotti, Silvia, Santos, Nuno, Amorim, Maria João, Pereira, Cristina Silva, Veldhoen, Marc, Ferreira, Cristina
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/165739
Summary: Funding Information: We would like to thank the excellent contributions from the iMM flow cytometry, rodent, and microscopy facilities. The project that gave rise to these results has received funding from the following sources:”la Caixa” Foundation under the grant agreement LCF/PR/HR19/52160005; European Union’s Horizon 2020 Research and Innovation Programme under grant agreements No 667824; FCT - Portuguese Foundation for Science and Technology under grant agreements (PD/BD/138847/2018) (COVID/BD/152538/2022) (L.B.) SFRH/BD/131605/2017 (P.F-C), COMPETE LISBOA-01-0145-FEDER-028003, and 2021.01136.CEECIND (C.F), FCT - Fundação para a Ciência e a Tecnologia, I.P., under the project LA/P/0082/2020, for work in the Veldhoen laboratory: and FCT PD/BD/135481/2018 (D.P.), UIDB/04612/2020, UIDP/04612/2020 and LA/P/0087/2020 for work in the Silva Pereira laboratory; FCG - Fundação Calouste Gulbenkian within the Post-Graduation Programme for Science and Development (N.S.), FCT CEECIND/02373/2020 and FCG, FCT and ”la Caixa” Foundation under the grant agreement HR22-00722 for work in the Amorim laboratory. The authors wish to acknowledge Brian Chan and Pedro Papotto, Lydia Becker Institute for Immunology & Inflammation, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom for the delivery of N. brasiliensis. Funding Information: We would like to thank the excellent contributions from the iMM flow cytometry, rodent, and microscopy facilities. The project that gave rise to these results has received funding from the following sources:”la Caixa” Foundation under the grant agreement LCF/PR/HR19/52160005; European Union’s Horizon 2020 Research and Innovation Programme under grant agreements No 667824; FCT - Portuguese Foundation for Science and Technology under grant agreements (PD/BD/138847/2018) (COVID/BD/152538/2022) (L.B.) SFRH/BD/131605/2017 (P.F-C), COMPETE LISBOA-01-0145-FEDER-028003, and 2021.01136.CEECIND (C.F), FCT - Fundação para a Ciência e a Tecnologia, I.P., under the project LA/P/0082/2020, for work in the Veldhoen laboratory: and FCT PD/BD/135481/2018 (D.P.), UIDB/04612/2020, UIDP/04612/2020 and LA/P/0087/2020 for work in the Silva Pereira laboratory; FCG - Fundação Calouste Gulbenkian within the Post-Graduation Programme for Science and Development (N.S.), FCT CEECIND/02373/2020 and FCG, FCT and ”la Caixa” Foundation under the grant agreement HR22-00722 for work in the Amorim laboratory. The authors wish to acknowledge Brian Chan and Pedro Papotto, Lydia Becker Institute for Immunology & Inflammation, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom for the delivery of N. brasiliensis. Publisher Copyright: © 2023, Springer Nature Limited.
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spelling CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell typesChemistry(all)Biochemistry, Genetics and Molecular Biology(all)Physics and Astronomy(all)SDG 3 - Good Health and Well-beingFunding Information: We would like to thank the excellent contributions from the iMM flow cytometry, rodent, and microscopy facilities. The project that gave rise to these results has received funding from the following sources:”la Caixa” Foundation under the grant agreement LCF/PR/HR19/52160005; European Union’s Horizon 2020 Research and Innovation Programme under grant agreements No 667824; FCT - Portuguese Foundation for Science and Technology under grant agreements (PD/BD/138847/2018) (COVID/BD/152538/2022) (L.B.) SFRH/BD/131605/2017 (P.F-C), COMPETE LISBOA-01-0145-FEDER-028003, and 2021.01136.CEECIND (C.F), FCT - Fundação para a Ciência e a Tecnologia, I.P., under the project LA/P/0082/2020, for work in the Veldhoen laboratory: and FCT PD/BD/135481/2018 (D.P.), UIDB/04612/2020, UIDP/04612/2020 and LA/P/0087/2020 for work in the Silva Pereira laboratory; FCG - Fundação Calouste Gulbenkian within the Post-Graduation Programme for Science and Development (N.S.), FCT CEECIND/02373/2020 and FCG, FCT and ”la Caixa” Foundation under the grant agreement HR22-00722 for work in the Amorim laboratory. The authors wish to acknowledge Brian Chan and Pedro Papotto, Lydia Becker Institute for Immunology & Inflammation, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom for the delivery of N. brasiliensis. Funding Information: We would like to thank the excellent contributions from the iMM flow cytometry, rodent, and microscopy facilities. The project that gave rise to these results has received funding from the following sources:”la Caixa” Foundation under the grant agreement LCF/PR/HR19/52160005; European Union’s Horizon 2020 Research and Innovation Programme under grant agreements No 667824; FCT - Portuguese Foundation for Science and Technology under grant agreements (PD/BD/138847/2018) (COVID/BD/152538/2022) (L.B.) SFRH/BD/131605/2017 (P.F-C), COMPETE LISBOA-01-0145-FEDER-028003, and 2021.01136.CEECIND (C.F), FCT - Fundação para a Ciência e a Tecnologia, I.P., under the project LA/P/0082/2020, for work in the Veldhoen laboratory: and FCT PD/BD/135481/2018 (D.P.), UIDB/04612/2020, UIDP/04612/2020 and LA/P/0087/2020 for work in the Silva Pereira laboratory; FCG - Fundação Calouste Gulbenkian within the Post-Graduation Programme for Science and Development (N.S.), FCT CEECIND/02373/2020 and FCG, FCT and ”la Caixa” Foundation under the grant agreement HR22-00722 for work in the Amorim laboratory. The authors wish to acknowledge Brian Chan and Pedro Papotto, Lydia Becker Institute for Immunology & Inflammation, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom for the delivery of N. brasiliensis. Publisher Copyright: © 2023, Springer Nature Limited.Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, however, if CD8+ TRM cells develop under other infection types and require immune type-specific TREG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8+ TRM cells. Intracellular (type-1) and extracellular (type-3) infections do and rely on the recruitment of response type-matching TREG population contributing transforming growth factor-β. Nevertheless, type-1 TREG cells remain the most important population for TRM cell development. Once established, TRM cells maintain their immune type profile. These results may have implications in the development of vaccines inducing CD8+ TRM cells.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNBarros, LeandroPiontkivska, DarynaFigueiredo-Campos, PatríciaFanczal, JúliaRibeiro, Sofia PereiraBaptista, MartaAriotti, SilviaSantos, NunoAmorim, Maria JoãoPereira, Cristina SilvaVeldhoen, MarcFerreira, Cristina2024-04-02T23:51:59Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/165739eng2041-1723PURE: 83701434https://doi.org/10.1038/s41467-023-41364-winfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:20:08Zoai:run.unl.pt:10362/165739Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:50:53.286862Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
title CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
spellingShingle CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
Barros, Leandro
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
SDG 3 - Good Health and Well-being
title_short CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
title_full CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
title_fullStr CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
title_full_unstemmed CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
title_sort CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types
author Barros, Leandro
author_facet Barros, Leandro
Piontkivska, Daryna
Figueiredo-Campos, Patrícia
Fanczal, Júlia
Ribeiro, Sofia Pereira
Baptista, Marta
Ariotti, Silvia
Santos, Nuno
Amorim, Maria João
Pereira, Cristina Silva
Veldhoen, Marc
Ferreira, Cristina
author_role author
author2 Piontkivska, Daryna
Figueiredo-Campos, Patrícia
Fanczal, Júlia
Ribeiro, Sofia Pereira
Baptista, Marta
Ariotti, Silvia
Santos, Nuno
Amorim, Maria João
Pereira, Cristina Silva
Veldhoen, Marc
Ferreira, Cristina
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
RUN
dc.contributor.author.fl_str_mv Barros, Leandro
Piontkivska, Daryna
Figueiredo-Campos, Patrícia
Fanczal, Júlia
Ribeiro, Sofia Pereira
Baptista, Marta
Ariotti, Silvia
Santos, Nuno
Amorim, Maria João
Pereira, Cristina Silva
Veldhoen, Marc
Ferreira, Cristina
dc.subject.por.fl_str_mv Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
SDG 3 - Good Health and Well-being
topic Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
SDG 3 - Good Health and Well-being
description Funding Information: We would like to thank the excellent contributions from the iMM flow cytometry, rodent, and microscopy facilities. The project that gave rise to these results has received funding from the following sources:”la Caixa” Foundation under the grant agreement LCF/PR/HR19/52160005; European Union’s Horizon 2020 Research and Innovation Programme under grant agreements No 667824; FCT - Portuguese Foundation for Science and Technology under grant agreements (PD/BD/138847/2018) (COVID/BD/152538/2022) (L.B.) SFRH/BD/131605/2017 (P.F-C), COMPETE LISBOA-01-0145-FEDER-028003, and 2021.01136.CEECIND (C.F), FCT - Fundação para a Ciência e a Tecnologia, I.P., under the project LA/P/0082/2020, for work in the Veldhoen laboratory: and FCT PD/BD/135481/2018 (D.P.), UIDB/04612/2020, UIDP/04612/2020 and LA/P/0087/2020 for work in the Silva Pereira laboratory; FCG - Fundação Calouste Gulbenkian within the Post-Graduation Programme for Science and Development (N.S.), FCT CEECIND/02373/2020 and FCG, FCT and ”la Caixa” Foundation under the grant agreement HR22-00722 for work in the Amorim laboratory. The authors wish to acknowledge Brian Chan and Pedro Papotto, Lydia Becker Institute for Immunology & Inflammation, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom for the delivery of N. brasiliensis. Funding Information: We would like to thank the excellent contributions from the iMM flow cytometry, rodent, and microscopy facilities. The project that gave rise to these results has received funding from the following sources:”la Caixa” Foundation under the grant agreement LCF/PR/HR19/52160005; European Union’s Horizon 2020 Research and Innovation Programme under grant agreements No 667824; FCT - Portuguese Foundation for Science and Technology under grant agreements (PD/BD/138847/2018) (COVID/BD/152538/2022) (L.B.) SFRH/BD/131605/2017 (P.F-C), COMPETE LISBOA-01-0145-FEDER-028003, and 2021.01136.CEECIND (C.F), FCT - Fundação para a Ciência e a Tecnologia, I.P., under the project LA/P/0082/2020, for work in the Veldhoen laboratory: and FCT PD/BD/135481/2018 (D.P.), UIDB/04612/2020, UIDP/04612/2020 and LA/P/0087/2020 for work in the Silva Pereira laboratory; FCG - Fundação Calouste Gulbenkian within the Post-Graduation Programme for Science and Development (N.S.), FCT CEECIND/02373/2020 and FCG, FCT and ”la Caixa” Foundation under the grant agreement HR22-00722 for work in the Amorim laboratory. The authors wish to acknowledge Brian Chan and Pedro Papotto, Lydia Becker Institute for Immunology & Inflammation, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom for the delivery of N. brasiliensis. Publisher Copyright: © 2023, Springer Nature Limited.
publishDate 2023
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2023-12-01T00:00:00Z
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