Main drivers of (poly)phenol effects on human health

Detalhes bibliográficos
Autor(a) principal: Iglesias-Aguirre, Carlos E.
Data de Publicação: 2021
Outros Autores: Cortés-Martín, Adrián, Ávila-Gálvez, María A., Giménez-Bastida, Juan A., Selma, María V., González-Sarrías, Antonio, Espín, Juan Carlos
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/127904
Resumo: Funding Information: This research was supported by the Project PID2019-103914RB-I00 from the Ministry of Science and Innovation (MICINN, Spain) and by Fundación Séneca de la Región de Murcia (Spain), grant number 20880/PI/18. J.A.G.-B. was supported by a Standard European Marie Curie Fellowship from the European Commission. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 838991. A.C.M. and C.E.I.-A. are the holders of predoctoral grants from MINECO (grant number BES-2016-078098) and MICINN (grant number FPU18/03961) (Spain), respectively. Publisher Copyright: © 2021 The Royal Society of Chemistry.
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spelling Main drivers of (poly)phenol effects on human healthMetabolite production and/or gut microbiota-associated metabotypes?Food ScienceSDG 3 - Good Health and Well-beingFunding Information: This research was supported by the Project PID2019-103914RB-I00 from the Ministry of Science and Innovation (MICINN, Spain) and by Fundación Séneca de la Región de Murcia (Spain), grant number 20880/PI/18. J.A.G.-B. was supported by a Standard European Marie Curie Fellowship from the European Commission. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 838991. A.C.M. and C.E.I.-A. are the holders of predoctoral grants from MINECO (grant number BES-2016-078098) and MICINN (grant number FPU18/03961) (Spain), respectively. Publisher Copyright: © 2021 The Royal Society of Chemistry.Despite the high human interindividual variability in response to (poly)phenol consumption, the cause-and-effect relationship between some dietary (poly)phenols (flavanols and olive oil phenolics) and health effects (endothelial function and prevention of LDL oxidation, respectively) has been well established. Most of the variables affecting this interindividual variability have been identified (food matrix, gut microbiota, single-nucleotide-polymorphisms, etc.). However, the final drivers for the health effects of (poly)phenol consumption have not been fully identified. At least partially, these drivers could be (i) the (poly)phenols ingested that exert their effect in the gastrointestinal tract, (ii) the bioavailable metabolites that exert their effects systemically and/or (iii) the gut microbial ecology associated with (poly)phenol metabolism (i.e., gut microbiota-associated metabotypes). However, statistical associations between health effects and the occurrence of circulating and/or excreted metabolites, as well as cross-sectional studies that correlate gut microbial ecologies and health, do not prove a causal role unequivocally. We provide a critical overview and perspective on the possible main drivers of the effects of (poly)phenols on human health and suggest possible actions to identify the putative actors responsible for the effects.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNIglesias-Aguirre, Carlos E.Cortés-Martín, AdriánÁvila-Gálvez, María A.Giménez-Bastida, Juan A.Selma, María V.González-Sarrías, AntonioEspín, Juan Carlos2021-11-17T23:44:40Z2021-11-072021-11-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other32application/pdfhttp://hdl.handle.net/10362/127904eng2042-6496PURE: 34906218https://doi.org/10.1039/d1fo02033ainfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:57:14Zoai:run.unl.pt:10362/127904Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:28:12.677481Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Main drivers of (poly)phenol effects on human health
Metabolite production and/or gut microbiota-associated metabotypes?
title Main drivers of (poly)phenol effects on human health
spellingShingle Main drivers of (poly)phenol effects on human health
Iglesias-Aguirre, Carlos E.
Food Science
SDG 3 - Good Health and Well-being
title_short Main drivers of (poly)phenol effects on human health
title_full Main drivers of (poly)phenol effects on human health
title_fullStr Main drivers of (poly)phenol effects on human health
title_full_unstemmed Main drivers of (poly)phenol effects on human health
title_sort Main drivers of (poly)phenol effects on human health
author Iglesias-Aguirre, Carlos E.
author_facet Iglesias-Aguirre, Carlos E.
Cortés-Martín, Adrián
Ávila-Gálvez, María A.
Giménez-Bastida, Juan A.
Selma, María V.
González-Sarrías, Antonio
Espín, Juan Carlos
author_role author
author2 Cortés-Martín, Adrián
Ávila-Gálvez, María A.
Giménez-Bastida, Juan A.
Selma, María V.
González-Sarrías, Antonio
Espín, Juan Carlos
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Iglesias-Aguirre, Carlos E.
Cortés-Martín, Adrián
Ávila-Gálvez, María A.
Giménez-Bastida, Juan A.
Selma, María V.
González-Sarrías, Antonio
Espín, Juan Carlos
dc.subject.por.fl_str_mv Food Science
SDG 3 - Good Health and Well-being
topic Food Science
SDG 3 - Good Health and Well-being
description Funding Information: This research was supported by the Project PID2019-103914RB-I00 from the Ministry of Science and Innovation (MICINN, Spain) and by Fundación Séneca de la Región de Murcia (Spain), grant number 20880/PI/18. J.A.G.-B. was supported by a Standard European Marie Curie Fellowship from the European Commission. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 838991. A.C.M. and C.E.I.-A. are the holders of predoctoral grants from MINECO (grant number BES-2016-078098) and MICINN (grant number FPU18/03961) (Spain), respectively. Publisher Copyright: © 2021 The Royal Society of Chemistry.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-17T23:44:40Z
2021-11-07
2021-11-07T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/127904
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 2042-6496
PURE: 34906218
https://doi.org/10.1039/d1fo02033a
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