Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients

Bibliographic Details
Main Author: COVIP Study Group
Publication Date: 2023
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/150641
Summary: Funding Information: Open access funding provided by University of Innsbruck and Medical University of Innsbruck. The support of the study in France by a grant from Fondation Assistance Publique-Hôpitaux de Paris pour la recherche is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was funded by a grant from the European Open Science Cloud (EOSC) by the European Commission. No further specific funding was received. Publisher Copyright: © 2023, The Author(s).
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spelling Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patientsa multicenter prospective observational cohort studyCritical careElderlyIntensive care unitOldRisk factorsSARS-CoV-2VentilationMicrobiology (medical)Infectious DiseasesSDG 3 - Good Health and Well-beingFunding Information: Open access funding provided by University of Innsbruck and Medical University of Innsbruck. The support of the study in France by a grant from Fondation Assistance Publique-Hôpitaux de Paris pour la recherche is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was funded by a grant from the European Open Science Cloud (EOSC) by the European Commission. No further specific funding was received. Publisher Copyright: © 2023, The Author(s).Background: Several studies have found an association between diabetes mellitus, disease severity and outcome in COVID-19 patients. Old critically ill patients are particularly at risk. This study aimed to investigate the impact of diabetes mellitus on 90-day mortality in a high-risk cohort of critically ill patients over 70 years of age. Methods: This multicentre international prospective cohort study was performed in 151 ICUs across 26 countries. We included patients ≥ 70 years of age with a confirmed SARS-CoV-2 infection admitted to the intensive care unit from 19th March 2020 through 15th July 2021. Patients were categorized into two groups according to the presence of diabetes mellitus. Primary outcome was 90-day mortality. Kaplan–Meier overall survival curves until day 90 were analysed and compared using the log-rank test. Mixed-effect Weibull regression models were computed to investigate the influence of diabetes mellitus on 90-day mortality. Results: This study included 3420 patients with a median age of 76 years were included. Among these, 37.3% (n = 1277) had a history of diabetes mellitus. Patients with diabetes showed higher rates of frailty (32% vs. 18%) and several comorbidities including chronic heart failure (20% vs. 11%), hypertension (79% vs. 59%) and chronic kidney disease (25% vs. 11%), but not of pulmonary comorbidities (22% vs. 22%). The 90-day mortality was significantly higher in patients with diabetes than those without diabetes (64% vs. 56%, p < 0.001). The association of diabetes and 90-day mortality remained significant (HR 1.18 [1.06–1.31], p = 0.003) after adjustment for age, sex, SOFA-score and other comorbidities in a Weibull regression analysis. Conclusion: Diabetes mellitus was a relevant risk factor for 90-day mortality in old critically ill patients with COVID-19. Study registration: NCT04321265, registered March 19th, 2020.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCOVIP Study Group2023-03-15T22:33:15Z2023-102023-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/150641eng0300-8126PURE: 55861190https://doi.org/10.1007/s15010-023-02001-2info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:10:01Zoai:run.unl.pt:10362/150641Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:40:40.770438Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients
a multicenter prospective observational cohort study
title Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients
spellingShingle Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients
COVIP Study Group
Critical care
Elderly
Intensive care unit
Old
Risk factors
SARS-CoV-2
Ventilation
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients
title_full Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients
title_fullStr Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients
title_full_unstemmed Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients
title_sort Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients
author COVIP Study Group
author_facet COVIP Study Group
author_role author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv COVIP Study Group
dc.subject.por.fl_str_mv Critical care
Elderly
Intensive care unit
Old
Risk factors
SARS-CoV-2
Ventilation
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
topic Critical care
Elderly
Intensive care unit
Old
Risk factors
SARS-CoV-2
Ventilation
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
description Funding Information: Open access funding provided by University of Innsbruck and Medical University of Innsbruck. The support of the study in France by a grant from Fondation Assistance Publique-Hôpitaux de Paris pour la recherche is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was funded by a grant from the European Open Science Cloud (EOSC) by the European Commission. No further specific funding was received. Publisher Copyright: © 2023, The Author(s).
publishDate 2023
dc.date.none.fl_str_mv 2023-03-15T22:33:15Z
2023-10
2023-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150641
url http://hdl.handle.net/10362/150641
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0300-8126
PURE: 55861190
https://doi.org/10.1007/s15010-023-02001-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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