Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis

Detalhes bibliográficos
Autor(a) principal: Antunes, Daniela
Data de Publicação: 2019
Outros Autores: Cunha, Cristina, Carvalho, Agostinho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/1822/62275
Resumo: Purpose of Review There is significant interindividual variability in the development and progression of fungal diseases, most notably invasive pulmonary aspergillosis (IPA). The integration of individual traits into clinically valid procedures to predict the risk and progression of infection, and the efficacy of antifungal prophylaxis and therapy, will change the current healthcare landscape regarding the management of patients at risk of IPA and, likely, other fungal infections. Recent Findings Over the last decade, an expanding number of common polymorphisms associated with IPA have been reported, adding to the information available on monogenic defects underlying severe forms of the disease. Predisposition to IPA is therefore nowadays considered to result from a combination of clinical and host factors, with the latter being most likely regulated at the genetic level. Summary In this review, we address the contribution of the genetic profile of the host to the outcome of the host-fungus interaction and discuss the application of this information in potential strategies with the aim of moving towards personalized prognostics, diagnostics, and treatment.
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spelling Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of AspergillosisAspergillosisImmunocompromised hostSingle nucleotide polymorphism (SNP)Genetic susceptibilityAntifungal immunityPersonalized medicineCiências Médicas::Medicina BásicaScience & TechnologyPurpose of Review There is significant interindividual variability in the development and progression of fungal diseases, most notably invasive pulmonary aspergillosis (IPA). The integration of individual traits into clinically valid procedures to predict the risk and progression of infection, and the efficacy of antifungal prophylaxis and therapy, will change the current healthcare landscape regarding the management of patients at risk of IPA and, likely, other fungal infections. Recent Findings Over the last decade, an expanding number of common polymorphisms associated with IPA have been reported, adding to the information available on monogenic defects underlying severe forms of the disease. Predisposition to IPA is therefore nowadays considered to result from a combination of clinical and host factors, with the latter being most likely regulated at the genetic level. Summary In this review, we address the contribution of the genetic profile of the host to the outcome of the host-fungus interaction and discuss the application of this information in potential strategies with the aim of moving towards personalized prognostics, diagnostics, and treatment.Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013); the Fundação para a Ciência e Tecnologia (FCT) (IF/00735/2014 and CEECIND/03628/2017); and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID Research Grant 2017). Cristina Cunha reports funding from the Fundação para a Ciência e Tecnologia (FCT) (PTDC/SAU-SER/29635/2017 and CEECIND/04601/2017) and the Institut Mérieux (Mérieux Research Grant 2017)SpringerUniversidade do MinhoAntunes, DanielaCunha, CristinaCarvalho, Agostinho20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/62275engAntunes, D., Cunha, C., & Carvalho, A. (2019). Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis. Current Fungal Infection Reports, 13(3), 77-85.1936-37611936-377X10.1007/s12281-019-00344-8https://link.springer.com/article/10.1007/s12281-019-00344-8info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T05:25:07Zoai:repositorium.sdum.uminho.pt:1822/62275Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:17:57.810698Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
title Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
spellingShingle Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
Antunes, Daniela
Aspergillosis
Immunocompromised host
Single nucleotide polymorphism (SNP)
Genetic susceptibility
Antifungal immunity
Personalized medicine
Ciências Médicas::Medicina Básica
Science & Technology
title_short Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
title_full Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
title_fullStr Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
title_full_unstemmed Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
title_sort Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
author Antunes, Daniela
author_facet Antunes, Daniela
Cunha, Cristina
Carvalho, Agostinho
author_role author
author2 Cunha, Cristina
Carvalho, Agostinho
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Antunes, Daniela
Cunha, Cristina
Carvalho, Agostinho
dc.subject.por.fl_str_mv Aspergillosis
Immunocompromised host
Single nucleotide polymorphism (SNP)
Genetic susceptibility
Antifungal immunity
Personalized medicine
Ciências Médicas::Medicina Básica
Science & Technology
topic Aspergillosis
Immunocompromised host
Single nucleotide polymorphism (SNP)
Genetic susceptibility
Antifungal immunity
Personalized medicine
Ciências Médicas::Medicina Básica
Science & Technology
description Purpose of Review There is significant interindividual variability in the development and progression of fungal diseases, most notably invasive pulmonary aspergillosis (IPA). The integration of individual traits into clinically valid procedures to predict the risk and progression of infection, and the efficacy of antifungal prophylaxis and therapy, will change the current healthcare landscape regarding the management of patients at risk of IPA and, likely, other fungal infections. Recent Findings Over the last decade, an expanding number of common polymorphisms associated with IPA have been reported, adding to the information available on monogenic defects underlying severe forms of the disease. Predisposition to IPA is therefore nowadays considered to result from a combination of clinical and host factors, with the latter being most likely regulated at the genetic level. Summary In this review, we address the contribution of the genetic profile of the host to the outcome of the host-fungus interaction and discuss the application of this information in potential strategies with the aim of moving towards personalized prognostics, diagnostics, and treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/62275
url https://hdl.handle.net/1822/62275
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antunes, D., Cunha, C., & Carvalho, A. (2019). Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis. Current Fungal Infection Reports, 13(3), 77-85.
1936-3761
1936-377X
10.1007/s12281-019-00344-8
https://link.springer.com/article/10.1007/s12281-019-00344-8
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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