Digitoxin: overdose in pharmaceutical compounded preparation

Bibliographic Details
Main Author: Yano, Helena Miyoco
Publication Date: 2005
Other Authors: Auricchio, Mariângela Tirico
Format: Article
Language: por
Source: Revista do Instituto Adolfo Lutz (Online)
Download full: https://periodicos.saude.sp.gov.br/RIAL/article/view/32996
Summary: The authors report a case on an inaccurate pharmacy compounding of digitoxin compounded preparation, which revealed an amount of 565% of active digitoxin in reference to that concentration stated in the label. The preparation analysis request was sent with a clinical record and sanitary authority notification on severe digitalic intoxication symptoms presented by the patient after taking that medication. The reported episode points up the lack of quality control at compounding pharmacies during dispensing drugs and compounds, with narrow therapeutic indices as digitalis drug preparations.
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spelling Digitoxin: overdose in pharmaceutical compounded preparationDigitoxina: superdosagem em medicamento manipuladodigitoxinpharmaceutical compoundingquality controldigitoxinamedicamento manipuladocontrole de qualidadeThe authors report a case on an inaccurate pharmacy compounding of digitoxin compounded preparation, which revealed an amount of 565% of active digitoxin in reference to that concentration stated in the label. The preparation analysis request was sent with a clinical record and sanitary authority notification on severe digitalic intoxication symptoms presented by the patient after taking that medication. The reported episode points up the lack of quality control at compounding pharmacies during dispensing drugs and compounds, with narrow therapeutic indices as digitalis drug preparations.Este relato de caso aborda medicamento manipulado em farmácia magistral, que apresentou teor da substância ativa Digitoxina de 565% em relação ao declarado em sua rotulagem. A solicitação da análise do medicamento veio acompanhada de informe do médico e da autoridade sanitária, na qual o paciente apresentou quadro de intoxicação grave após uso. Este episódio ilustra a dificuldade da garantia da qualidade em estabelecimento de farmácias magistrais, no processo da manipulação de medicamentos de fármacos com índice terapêutico estreito como neste caso dos digitálicos.Instituto Adolfo Lutz2005-02-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/RIAL/article/view/3299610.53393/rial.2005.64.32996Instituto Adolfo Lutz Journal - RIAL; Vol. 64 No. 2 (2005); 273-275Revista del Instituto Adolfo Lutz - RIAL; Vol. 64 Núm. 2 (2005); 273-275Revista do Instituto Adolfo Lutz; v. 64 n. 2 (2005); 273-2751983-38140073-9855reponame:Revista do Instituto Adolfo Lutz (Online)instname:Instituto Adolfo Lutzinstacron:IALporhttps://periodicos.saude.sp.gov.br/RIAL/article/view/32996/31828Copyright (c) 2005 Helena Miyoco Yano, Mariângela Tirico Auricchioinfo:eu-repo/semantics/openAccessYano, Helena MiyocoAuricchio, Mariângela Tirico2024-01-23T12:25:46Zoai:ojs.periodicos.saude.sp.gov.br:article/32996Revistahttps://periodicos.saude.sp.gov.br/RIAL/indexPUBhttps://periodicos.saude.sp.gov.br/RIAL/oairial@saude.sp.gov.brhttps://doi.org/10.53393/rial1983-38140073-9855opendoar:2024-01-23T12:25:46Revista do Instituto Adolfo Lutz (Online) - Instituto Adolfo Lutzfalse
dc.title.none.fl_str_mv Digitoxin: overdose in pharmaceutical compounded preparation
Digitoxina: superdosagem em medicamento manipulado
title Digitoxin: overdose in pharmaceutical compounded preparation
spellingShingle Digitoxin: overdose in pharmaceutical compounded preparation
Yano, Helena Miyoco
digitoxin
pharmaceutical compounding
quality control
digitoxina
medicamento manipulado
controle de qualidade
title_short Digitoxin: overdose in pharmaceutical compounded preparation
title_full Digitoxin: overdose in pharmaceutical compounded preparation
title_fullStr Digitoxin: overdose in pharmaceutical compounded preparation
title_full_unstemmed Digitoxin: overdose in pharmaceutical compounded preparation
title_sort Digitoxin: overdose in pharmaceutical compounded preparation
author Yano, Helena Miyoco
author_facet Yano, Helena Miyoco
Auricchio, Mariângela Tirico
author_role author
author2 Auricchio, Mariângela Tirico
author2_role author
dc.contributor.author.fl_str_mv Yano, Helena Miyoco
Auricchio, Mariângela Tirico
dc.subject.por.fl_str_mv digitoxin
pharmaceutical compounding
quality control
digitoxina
medicamento manipulado
controle de qualidade
topic digitoxin
pharmaceutical compounding
quality control
digitoxina
medicamento manipulado
controle de qualidade
description The authors report a case on an inaccurate pharmacy compounding of digitoxin compounded preparation, which revealed an amount of 565% of active digitoxin in reference to that concentration stated in the label. The preparation analysis request was sent with a clinical record and sanitary authority notification on severe digitalic intoxication symptoms presented by the patient after taking that medication. The reported episode points up the lack of quality control at compounding pharmacies during dispensing drugs and compounds, with narrow therapeutic indices as digitalis drug preparations.
publishDate 2005
dc.date.none.fl_str_mv 2005-02-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/RIAL/article/view/32996
10.53393/rial.2005.64.32996
url https://periodicos.saude.sp.gov.br/RIAL/article/view/32996
identifier_str_mv 10.53393/rial.2005.64.32996
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/RIAL/article/view/32996/31828
dc.rights.driver.fl_str_mv Copyright (c) 2005 Helena Miyoco Yano, Mariângela Tirico Auricchio
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2005 Helena Miyoco Yano, Mariângela Tirico Auricchio
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Adolfo Lutz
publisher.none.fl_str_mv Instituto Adolfo Lutz
dc.source.none.fl_str_mv Instituto Adolfo Lutz Journal - RIAL; Vol. 64 No. 2 (2005); 273-275
Revista del Instituto Adolfo Lutz - RIAL; Vol. 64 Núm. 2 (2005); 273-275
Revista do Instituto Adolfo Lutz; v. 64 n. 2 (2005); 273-275
1983-3814
0073-9855
reponame:Revista do Instituto Adolfo Lutz (Online)
instname:Instituto Adolfo Lutz
instacron:IAL
instname_str Instituto Adolfo Lutz
instacron_str IAL
institution IAL
reponame_str Revista do Instituto Adolfo Lutz (Online)
collection Revista do Instituto Adolfo Lutz (Online)
repository.name.fl_str_mv Revista do Instituto Adolfo Lutz (Online) - Instituto Adolfo Lutz
repository.mail.fl_str_mv rial@saude.sp.gov.br
_version_ 1836991959046029312

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