Intoxication by Colchicine in a compounded pharmaceutical formulation

Bibliographic Details
Main Author: Yano, Helena Miyoco
Publication Date: 2008
Other Authors: Bugno, Adriana, Auricchio, Mariângela Tirico
Format: Article
Language: por
Source: Revista do Instituto Adolfo Lutz (Online)
Download full: https://periodicos.saude.sp.gov.br/RIAL/article/view/32772
Summary: The present work relate a case of overdose of colchicine in a capsules of compounded pharmaceutical formulation whose ingestion dose initiated a process of acute gastrointestinal haemorrhage leading the patient to death. Colchicine is a pharmacon of low therapeutical index drug, and the maximum recommended dose for gout treatment in adult is 2.5 mg at the first 24 hours. The remaining non- ingested capsules were analyzed by spectrophotometry, and colchicine amount was determined according to the Brazilian Pharmacopoeia, IV edition. The average dosage was of 47.36 mg, that is, about 20 times higher than the maximum recommended dose. The dosage mistake was evidenced in the medicament prescription, and also in consultation the professional responsible for prescribing the medicine on the part of operator who processed the colchicines formulation.
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spelling Intoxication by Colchicine in a compounded pharmaceutical formulationIntoxicação por colchicina em formulação manipuladacolchicinecompounded pharmaceutical formulationoverdosecolchicinamedicamento manipuladosuperdosagemThe present work relate a case of overdose of colchicine in a capsules of compounded pharmaceutical formulation whose ingestion dose initiated a process of acute gastrointestinal haemorrhage leading the patient to death. Colchicine is a pharmacon of low therapeutical index drug, and the maximum recommended dose for gout treatment in adult is 2.5 mg at the first 24 hours. The remaining non- ingested capsules were analyzed by spectrophotometry, and colchicine amount was determined according to the Brazilian Pharmacopoeia, IV edition. The average dosage was of 47.36 mg, that is, about 20 times higher than the maximum recommended dose. The dosage mistake was evidenced in the medicament prescription, and also in consultation the professional responsible for prescribing the medicine on the part of operator who processed the colchicines formulation.O presente trabalho relata um caso de superdosagem de colchicina em cápsulas manipuladas cuja ingestão inicial ocasionou um processo de hemorragia digestiva aguda levando o paciente a óbito. A colchicina é um fármaco de baixo índice terapêutico, cuja dose máxima recomendada para o tratamento de gota é de 2,5 mg, nas primeiras 24 horas para adultos. Nas cápsulas restantes, não ingeridas, a dosagem média de colchicina, determinada por espectrofotometria (segundo a Farmacopéia Brasileira IV edição) foi de 47,36 mg ou seja, cerca de 20 vezes maior que a dose máxima recomendada. O erro foi constatado na prescrição e na consulta ao prescritor por parte do manipulador do medicamento.Instituto Adolfo Lutz2008-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado pelos paresapplication/pdfhttps://periodicos.saude.sp.gov.br/RIAL/article/view/3277210.53393/rial.2008.67.32772Instituto Adolfo Lutz Journal - RIAL; Vol. 67 No. 3 (2008); 234-236Revista del Instituto Adolfo Lutz - RIAL; Vol. 67 Núm. 3 (2008); 234-236Revista do Instituto Adolfo Lutz; v. 67 n. 3 (2008); 234-2361983-38140073-9855reponame:Revista do Instituto Adolfo Lutz (Online)instname:Instituto Adolfo Lutzinstacron:IALporhttps://periodicos.saude.sp.gov.br/RIAL/article/view/32772/31603Copyright (c) 2008 Helena Miyoco Yano, Adriana Bugno, Mariângela Tirico Auricchioinfo:eu-repo/semantics/openAccessYano, Helena MiyocoBugno, AdrianaAuricchio, Mariângela Tirico2024-01-22T17:33:50Zoai:ojs.periodicos.saude.sp.gov.br:article/32772Revistahttps://periodicos.saude.sp.gov.br/RIAL/indexPUBhttps://periodicos.saude.sp.gov.br/RIAL/oairial@saude.sp.gov.brhttps://doi.org/10.53393/rial1983-38140073-9855opendoar:2024-01-22T17:33:50Revista do Instituto Adolfo Lutz (Online) - Instituto Adolfo Lutzfalse
dc.title.none.fl_str_mv Intoxication by Colchicine in a compounded pharmaceutical formulation
Intoxicação por colchicina em formulação manipulada
title Intoxication by Colchicine in a compounded pharmaceutical formulation
spellingShingle Intoxication by Colchicine in a compounded pharmaceutical formulation
Yano, Helena Miyoco
colchicine
compounded pharmaceutical formulation
overdose
colchicina
medicamento manipulado
superdosagem
title_short Intoxication by Colchicine in a compounded pharmaceutical formulation
title_full Intoxication by Colchicine in a compounded pharmaceutical formulation
title_fullStr Intoxication by Colchicine in a compounded pharmaceutical formulation
title_full_unstemmed Intoxication by Colchicine in a compounded pharmaceutical formulation
title_sort Intoxication by Colchicine in a compounded pharmaceutical formulation
author Yano, Helena Miyoco
author_facet Yano, Helena Miyoco
Bugno, Adriana
Auricchio, Mariângela Tirico
author_role author
author2 Bugno, Adriana
Auricchio, Mariângela Tirico
author2_role author
author
dc.contributor.author.fl_str_mv Yano, Helena Miyoco
Bugno, Adriana
Auricchio, Mariângela Tirico
dc.subject.por.fl_str_mv colchicine
compounded pharmaceutical formulation
overdose
colchicina
medicamento manipulado
superdosagem
topic colchicine
compounded pharmaceutical formulation
overdose
colchicina
medicamento manipulado
superdosagem
description The present work relate a case of overdose of colchicine in a capsules of compounded pharmaceutical formulation whose ingestion dose initiated a process of acute gastrointestinal haemorrhage leading the patient to death. Colchicine is a pharmacon of low therapeutical index drug, and the maximum recommended dose for gout treatment in adult is 2.5 mg at the first 24 hours. The remaining non- ingested capsules were analyzed by spectrophotometry, and colchicine amount was determined according to the Brazilian Pharmacopoeia, IV edition. The average dosage was of 47.36 mg, that is, about 20 times higher than the maximum recommended dose. The dosage mistake was evidenced in the medicament prescription, and also in consultation the professional responsible for prescribing the medicine on the part of operator who processed the colchicines formulation.
publishDate 2008
dc.date.none.fl_str_mv 2008-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.saude.sp.gov.br/RIAL/article/view/32772
10.53393/rial.2008.67.32772
url https://periodicos.saude.sp.gov.br/RIAL/article/view/32772
identifier_str_mv 10.53393/rial.2008.67.32772
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.saude.sp.gov.br/RIAL/article/view/32772/31603
dc.rights.driver.fl_str_mv Copyright (c) 2008 Helena Miyoco Yano, Adriana Bugno, Mariângela Tirico Auricchio
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2008 Helena Miyoco Yano, Adriana Bugno, Mariângela Tirico Auricchio
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Adolfo Lutz
publisher.none.fl_str_mv Instituto Adolfo Lutz
dc.source.none.fl_str_mv Instituto Adolfo Lutz Journal - RIAL; Vol. 67 No. 3 (2008); 234-236
Revista del Instituto Adolfo Lutz - RIAL; Vol. 67 Núm. 3 (2008); 234-236
Revista do Instituto Adolfo Lutz; v. 67 n. 3 (2008); 234-236
1983-3814
0073-9855
reponame:Revista do Instituto Adolfo Lutz (Online)
instname:Instituto Adolfo Lutz
instacron:IAL
instname_str Instituto Adolfo Lutz
instacron_str IAL
institution IAL
reponame_str Revista do Instituto Adolfo Lutz (Online)
collection Revista do Instituto Adolfo Lutz (Online)
repository.name.fl_str_mv Revista do Instituto Adolfo Lutz (Online) - Instituto Adolfo Lutz
repository.mail.fl_str_mv rial@saude.sp.gov.br
_version_ 1836991957324267520

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