Decoding the Role of Glycans in Malaria
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3389/fmicb.2017.01071 |
| Texto Completo: | https://arca.fiocruz.br/handle/icict/20036 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq) and the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). |
| id |
CRUZ_cc884c5ee64b85e9893d855cd52faf6c |
|---|---|
| oai_identifier_str |
oai:arca.fiocruz.br:icict/20036 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Gomes, Pollyanna StephanieFeijó, Daniel FerreiraMorrot, AlexandreFreire-De-Lima, Celio Geraldo2017-07-11T12:43:47Z2017-07-11T12:43:47Z2017GOMES, Pollyanna Stephanie et al. Decoding the Role of Glycans in Malaria. Frontiers in Microbiology, v. 8, Article 1071, p. 1-12, June 2017.1664-302Xhttps://arca.fiocruz.br/handle/icict/2003610.3389/fmicb.2017.01071Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq) and the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ).Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilComplications arising from malaria are a concern for public health authorities worldwide, since the annual caseload in humans usually exceeds millions. Of more than 160 species of Plasmodium, only 4 infect humans, with the most severe cases ascribed to Plasmodium falciparum and the most prevalent to Plasmodium vivax. Over the past 70 years, since World War II, when the first antimalarial drugs were widely used, many efforts have been made to combat this disease, including vectorial control, new drug discoveries and genetic and molecular approaches. Molecular approaches, such as glycobiology, may lead to new therapeutic targets (both in the host and the parasites), since all interactions are mediated by carbohydrates or glycan moieties decorating both cellular surfaces from parasite and host cells. In this review, we address the carbohydrate-mediated glycobiology that directly affects Plasmodium survival or host resistance.porFrontiers Research FoundationMaláriaGlicobiologiaAlvos de carboidratosPlasmodium falciparumMalariaGlycobiologyCarbohydrate-targetsPlasmodium falciparumDecoding the Role of Glycans in Malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/f2edc04b-f144-45ad-a776-72ce09c667d4/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALGomes PS Decoding the role....pdfGomes PS Decoding the role....pdfapplication/pdf318761https://arca.fiocruz.br/bitstreams/08e309f7-3266-4d1a-a2ce-bdc2b4f8fe92/download7b7f10672cf6d1dfc4189dd62df4d2f3MD52trueAnonymousREADTEXTGomes PS Decoding the role....pdf.txtGomes PS Decoding the role....pdf.txtExtracted texttext/plain34083https://arca.fiocruz.br/bitstreams/4168bab6-446b-40fe-a7c6-e5cc32d3da79/downloadc09c977f1d68a549d560d17ef67aa626MD55falseAnonymousREADTHUMBNAILGomes PS Decoding the role....pdf.jpgGomes PS Decoding the role....pdf.jpgGenerated Thumbnailimage/jpeg5367https://arca.fiocruz.br/bitstreams/812fc770-6212-481b-855c-8d571ae75772/downloadd59a5c1b63edf237860002774509d078MD56falseAnonymousREADicict/200362025-07-30 01:35:18.025open.accessoai:arca.fiocruz.br:icict/20036https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T04:35:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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 |
| dc.title.none.fl_str_mv |
Decoding the Role of Glycans in Malaria |
| title |
Decoding the Role of Glycans in Malaria |
| spellingShingle |
Decoding the Role of Glycans in Malaria Gomes, Pollyanna Stephanie Malária Glicobiologia Alvos de carboidratos Plasmodium falciparum Malaria Glycobiology Carbohydrate-targets Plasmodium falciparum |
| title_short |
Decoding the Role of Glycans in Malaria |
| title_full |
Decoding the Role of Glycans in Malaria |
| title_fullStr |
Decoding the Role of Glycans in Malaria |
| title_full_unstemmed |
Decoding the Role of Glycans in Malaria |
| title_sort |
Decoding the Role of Glycans in Malaria |
| author |
Gomes, Pollyanna Stephanie |
| author_facet |
Gomes, Pollyanna Stephanie Feijó, Daniel Ferreira Morrot, Alexandre Freire-De-Lima, Celio Geraldo |
| author_role |
author |
| author2 |
Feijó, Daniel Ferreira Morrot, Alexandre Freire-De-Lima, Celio Geraldo |
| author2_role |
author author author |
| dc.contributor.author.fl_str_mv |
Gomes, Pollyanna Stephanie Feijó, Daniel Ferreira Morrot, Alexandre Freire-De-Lima, Celio Geraldo |
| dc.subject.other.none.fl_str_mv |
Malária Glicobiologia Alvos de carboidratos Plasmodium falciparum |
| topic |
Malária Glicobiologia Alvos de carboidratos Plasmodium falciparum Malaria Glycobiology Carbohydrate-targets Plasmodium falciparum |
| dc.subject.en.none.fl_str_mv |
Malaria Glycobiology Carbohydrate-targets Plasmodium falciparum |
| description |
Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq) and the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). |
| publishDate |
2017 |
| dc.date.accessioned.fl_str_mv |
2017-07-11T12:43:47Z |
| dc.date.available.fl_str_mv |
2017-07-11T12:43:47Z |
| dc.date.issued.fl_str_mv |
2017 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
GOMES, Pollyanna Stephanie et al. Decoding the Role of Glycans in Malaria. Frontiers in Microbiology, v. 8, Article 1071, p. 1-12, June 2017. |
| dc.identifier.uri.fl_str_mv |
https://arca.fiocruz.br/handle/icict/20036 |
| dc.identifier.issn.none.fl_str_mv |
1664-302X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2017.01071 |
| identifier_str_mv |
GOMES, Pollyanna Stephanie et al. Decoding the Role of Glycans in Malaria. Frontiers in Microbiology, v. 8, Article 1071, p. 1-12, June 2017. 1664-302X 10.3389/fmicb.2017.01071 |
| url |
https://arca.fiocruz.br/handle/icict/20036 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Research Foundation |
| publisher.none.fl_str_mv |
Frontiers Research Foundation |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://arca.fiocruz.br/bitstreams/f2edc04b-f144-45ad-a776-72ce09c667d4/download https://arca.fiocruz.br/bitstreams/08e309f7-3266-4d1a-a2ce-bdc2b4f8fe92/download https://arca.fiocruz.br/bitstreams/4168bab6-446b-40fe-a7c6-e5cc32d3da79/download https://arca.fiocruz.br/bitstreams/812fc770-6212-481b-855c-8d571ae75772/download |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 7b7f10672cf6d1dfc4189dd62df4d2f3 c09c977f1d68a549d560d17ef67aa626 d59a5c1b63edf237860002774509d078 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1839716383573671936 |