Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host

Bibliographic Details
Main Author: Gomes, Pollyanna Stephanie
Publication Date: 2019
Other Authors: Tanghe, Scott, Gallego-Delgado, Julio, Conde, Luciana, Lima, Leonardo Freire de, Lima, Ana Carolina, Lima, Celio Geraldo Freire de, Lima Junior, Josué da Costa, Moreira, Otacílio, Totino, Paulo, Rodriguez, Ana, Todeschini, Adriane Regina, Morrot, Alexandre
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3389/fmicb.2019.00305
Download full: https://arca.fiocruz.br/handle/icict/35460
Summary: Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil.
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spelling Gomes, Pollyanna StephanieTanghe, ScottGallego-Delgado, JulioConde, LucianaLima, Leonardo Freire deLima, Ana CarolinaLima, Celio Geraldo Freire deLima Junior, Josué da CostaMoreira, OtacílioTotino, PauloRodriguez, AnaTodeschini, Adriane ReginaMorrot, Alexandre2019-09-10T17:31:12Z2019-09-10T17:31:12Z2019GOMES, Pollyanna Stephanie et al. Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host. Frontiers in Microbiology, v. 10, p. 1-9, Feb. 2019.1664-302Xhttps://arca.fiocruz.br/handle/icict/3546010.3389/fmicb.2019.00305engFrontiers MediaPlasmodium falciparumGlicobiologiaMalária cerebralEstratégias de tratamentoParasitasPlasmodium falciparumGlycobyologyCerebral malariaTreatment strategiesParasitesTargeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Hostinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Faculdade de Medicina. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil.New York University School of Medicine. Department of Microbiology. Division of Parasitology. New York, NY, USA.New York University School of Medicine. Department of Microbiology. Division of Parasitology. New York, NY, USA.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.New York University School of Medicine. Department of Microbiology. Division of Parasitology. New York, NY, USA.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Glicobiologia Estrutural e Funcional. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Cerebral malaria (CM) is a clinical syndrome involving irreversible and lethal signs of brain injury associated to infection by parasites of the genus Plasmodium. The pathogenesis of CM derives from infection-induced proinflammatory cytokines associated with cytoadherence of parasitized red blood cells to brain microvasculature. Glycoconjugates are very abundant in the surface of Plasmodium spp., and are critical mediators of parasite virulence in host-pathogen interactions. Herein, we show that 6-Diazo-5-oxo-L-norleucine (DON) therapeutically used for blocking hexosamine biosynthetic pathway leads to recovery in experimental murine cerebral malaria. DON-induced protection was associated with decreased parasitism, which severely reduced Plasmodium transmission to mosquitoes. These findings point to a potential use of DON in combination therapies against malaria.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/b7b1f711-195f-4a77-bfb7-660476e50bf0/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALPauloTotino_OctacilioMoreira_etal_IOC_2019.df.pdfPauloTotino_OctacilioMoreira_etal_IOC_2019.df.pdfapplication/pdf2530418https://arca.fiocruz.br/bitstreams/e232c4c4-0905-4e58-bced-b48e654613cb/download9787f16e01c81af32190d50cbbcd2ba6MD52trueAnonymousREADTEXTPauloTotino_OctacilioMoreira_etal_IOC_2019.df.pdf.txtPauloTotino_OctacilioMoreira_etal_IOC_2019.df.pdf.txtExtracted texttext/plain54129https://arca.fiocruz.br/bitstreams/2a127f66-9eb4-4106-836f-a14f8bdd32b2/downloade1d5c678cd8f9454ebc7aad314ee9ebfMD55falseAnonymousREADTHUMBNAILPauloTotino_OctacilioMoreira_etal_IOC_2019.df.pdf.jpgPauloTotino_OctacilioMoreira_etal_IOC_2019.df.pdf.jpgGenerated Thumbnailimage/jpeg5728https://arca.fiocruz.br/bitstreams/cc44f937-a5af-4df4-ad1e-6f28f205af97/downloade54a2f2bb51685fcf22d26c22e10aceaMD56falseAnonymousREADicict/354602025-07-30 00:01:53.119open.accessoai:arca.fiocruz.br:icict/35460https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T03:01:53Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
title Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
spellingShingle Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
Gomes, Pollyanna Stephanie
Plasmodium falciparum
Glicobiologia
Malária cerebral
Estratégias de tratamento
Parasitas
Plasmodium falciparum
Glycobyology
Cerebral malaria
Treatment strategies
Parasites
title_short Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
title_full Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
title_fullStr Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
title_full_unstemmed Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
title_sort Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
author Gomes, Pollyanna Stephanie
author_facet Gomes, Pollyanna Stephanie
Tanghe, Scott
Gallego-Delgado, Julio
Conde, Luciana
Lima, Leonardo Freire de
Lima, Ana Carolina
Lima, Celio Geraldo Freire de
Lima Junior, Josué da Costa
Moreira, Otacílio
Totino, Paulo
Rodriguez, Ana
Todeschini, Adriane Regina
Morrot, Alexandre
author_role author
author2 Tanghe, Scott
Gallego-Delgado, Julio
Conde, Luciana
Lima, Leonardo Freire de
Lima, Ana Carolina
Lima, Celio Geraldo Freire de
Lima Junior, Josué da Costa
Moreira, Otacílio
Totino, Paulo
Rodriguez, Ana
Todeschini, Adriane Regina
Morrot, Alexandre
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Pollyanna Stephanie
Tanghe, Scott
Gallego-Delgado, Julio
Conde, Luciana
Lima, Leonardo Freire de
Lima, Ana Carolina
Lima, Celio Geraldo Freire de
Lima Junior, Josué da Costa
Moreira, Otacílio
Totino, Paulo
Rodriguez, Ana
Todeschini, Adriane Regina
Morrot, Alexandre
dc.subject.other.none.fl_str_mv Plasmodium falciparum
Glicobiologia
Malária cerebral
Estratégias de tratamento
Parasitas
topic Plasmodium falciparum
Glicobiologia
Malária cerebral
Estratégias de tratamento
Parasitas
Plasmodium falciparum
Glycobyology
Cerebral malaria
Treatment strategies
Parasites
dc.subject.en.none.fl_str_mv Plasmodium falciparum
Glycobyology
Cerebral malaria
Treatment strategies
Parasites
description Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-10T17:31:12Z
dc.date.available.fl_str_mv 2019-09-10T17:31:12Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Pollyanna Stephanie et al. Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host. Frontiers in Microbiology, v. 10, p. 1-9, Feb. 2019.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/35460
dc.identifier.issn.none.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2019.00305
identifier_str_mv GOMES, Pollyanna Stephanie et al. Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host. Frontiers in Microbiology, v. 10, p. 1-9, Feb. 2019.
1664-302X
10.3389/fmicb.2019.00305
url https://arca.fiocruz.br/handle/icict/35460
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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