Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pntd.0003094 |
| Texto Completo: | https://arca.fiocruz.br/handle/icict/10280 |
Resumo: | FAPERJ, Cnpq, PAPES, CAPES |
| id |
CRUZ_c85318e40b44ca1765c9bbdc1cf63dd4 |
|---|---|
| oai_identifier_str |
oai:arca.fiocruz.br:icict/10280 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Paes, Rodrigo AlmeidaOliveira, Manoel Marques Evangelista deFreitas, Dayvison Francis SaraivaValle, Antonio Carlos Francesconi doOliveira, Rosely Maria ZancopéGalhardo, Maria Clara Gutierrez2015-05-11T16:28:11Z2015-05-11T16:28:11Z2014PAES, Rodrigo Almeida et al. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations. Plos One, v. 8, n. 9, p.e3094, 2014.1932-6203https://arca.fiocruz.br/handle/icict/1028010.1371/journal.pntd.00030941932-6203FAPERJ, Cnpq, PAPES, CAPESFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Dermatologia Infecciosa. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Dermatologia Infecciosa. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Dermatologia Infecciosa. Rio de Janeiro, RJ, BrasilBackground: There have been several recent changes in the taxonomy of Sporothrix schenckii as well as new observations regarding the clinical aspects of sporotrichosis. In this study, we determined the identification of the Sporothrix species associated with both classic and unusual clinical aspects of sporotrichosis observed in the endemic area of sporotrichosis in Rio de Janeiro, Brazil. Methodology/Principal Findings: To verify whether S. brasiliensis is associated with clinical manifestations of sporotrichosis, a cross-sectional study was performed in which Sporothrix isolates from 50 patients with different clinical manifestations were analyzed and their isolates were studied by phenotypic and genotypic methods. Data from these patients revealed a distinct clinical picture and therapeutic response in infections caused by Sporothrix brasiliensis (n = 45) compared to patients with S. schenckii sensu stricto (n = 5). S. brasiliensis was associated with disseminated cutaneous infection without underlying disease, hypersensitivity reactions, and mucosal infection, whereas patients with S. schenckii presented with less severe and more often localized disease, similar to the majority of previously described sporotrichosis cases. Interestingly, S. brasiliensisinfected patients overall required shorter durations of itraconazole (median 16 weeks) compared to the individuals with S. schenckii (median 24 weeks). Conclusions/Significance: These findings suggest that Sporothrix species are linked to different clinical manifestations of sporotrichosis and that S. brasiliensis is effectively treated with oral itraconazole.engPublic Library of ScienceSporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSporothrixBrazil/ethnologySporotrichosisMycologySporothrixBrasil/etnologiaEsporotricoseMicologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://arca.fiocruz.br/bitstreams/dc38d258-81bf-4853-9fe7-4daf525a3c77/downloadafbdf7d7a9bcf771a1cc7edf5f618413MD51falseAnonymousREADORIGINALSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdfSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdfapplication/pdf3529297https://arca.fiocruz.br/bitstreams/75e9b756-fb1b-41b5-a415-616eaa95a23a/download58ad9775b03ce23302e91db1323da229MD52trueAnonymousREADTEXTSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdf.txtSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdf.txtExtracted texttext/plain43177https://arca.fiocruz.br/bitstreams/135c9d1a-42d2-41ce-aac9-65950c441bb4/download20fd227a96f16458b411b7355bb31934MD57falseAnonymousREADTHUMBNAILSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdf.jpgSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdf.jpgGenerated Thumbnailimage/jpeg6612https://arca.fiocruz.br/bitstreams/7f526b81-bea7-44e4-a5d8-28722a2c20df/download830c5872cf4236cd61bd3b1901425b24MD58falseAnonymousREADicict/102802025-07-29 18:24:34.769open.accessoai:arca.fiocruz.br:icict/10280https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T21:24:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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 |
| dc.title.none.fl_str_mv |
Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations |
| title |
Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations |
| spellingShingle |
Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations Paes, Rodrigo Almeida Sporothrix Brazil/ethnology Sporotrichosis Mycology Sporothrix Brasil/etnologia Esporotricose Micologia |
| title_short |
Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations |
| title_full |
Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations |
| title_fullStr |
Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations |
| title_full_unstemmed |
Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations |
| title_sort |
Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations |
| author |
Paes, Rodrigo Almeida |
| author_facet |
Paes, Rodrigo Almeida Oliveira, Manoel Marques Evangelista de Freitas, Dayvison Francis Saraiva Valle, Antonio Carlos Francesconi do Oliveira, Rosely Maria Zancopé Galhardo, Maria Clara Gutierrez |
| author_role |
author |
| author2 |
Oliveira, Manoel Marques Evangelista de Freitas, Dayvison Francis Saraiva Valle, Antonio Carlos Francesconi do Oliveira, Rosely Maria Zancopé Galhardo, Maria Clara Gutierrez |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Paes, Rodrigo Almeida Oliveira, Manoel Marques Evangelista de Freitas, Dayvison Francis Saraiva Valle, Antonio Carlos Francesconi do Oliveira, Rosely Maria Zancopé Galhardo, Maria Clara Gutierrez |
| dc.subject.en.none.fl_str_mv |
Sporothrix Brazil/ethnology Sporotrichosis Mycology |
| topic |
Sporothrix Brazil/ethnology Sporotrichosis Mycology Sporothrix Brasil/etnologia Esporotricose Micologia |
| dc.subject.decs.none.fl_str_mv |
Sporothrix Brasil/etnologia Esporotricose Micologia |
| description |
FAPERJ, Cnpq, PAPES, CAPES |
| publishDate |
2014 |
| dc.date.issued.fl_str_mv |
2014 |
| dc.date.accessioned.fl_str_mv |
2015-05-11T16:28:11Z |
| dc.date.available.fl_str_mv |
2015-05-11T16:28:11Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
PAES, Rodrigo Almeida et al. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations. Plos One, v. 8, n. 9, p.e3094, 2014. |
| dc.identifier.uri.fl_str_mv |
https://arca.fiocruz.br/handle/icict/10280 |
| dc.identifier.issn.none.fl_str_mv |
1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0003094 |
| dc.identifier.eissn.none.fl_str_mv |
1932-6203 |
| identifier_str_mv |
PAES, Rodrigo Almeida et al. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations. Plos One, v. 8, n. 9, p.e3094, 2014. 1932-6203 10.1371/journal.pntd.0003094 |
| url |
https://arca.fiocruz.br/handle/icict/10280 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Public Library of Science |
| publisher.none.fl_str_mv |
Public Library of Science |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://arca.fiocruz.br/bitstreams/dc38d258-81bf-4853-9fe7-4daf525a3c77/download https://arca.fiocruz.br/bitstreams/75e9b756-fb1b-41b5-a415-616eaa95a23a/download https://arca.fiocruz.br/bitstreams/135c9d1a-42d2-41ce-aac9-65950c441bb4/download https://arca.fiocruz.br/bitstreams/7f526b81-bea7-44e4-a5d8-28722a2c20df/download |
| bitstream.checksum.fl_str_mv |
afbdf7d7a9bcf771a1cc7edf5f618413 58ad9775b03ce23302e91db1323da229 20fd227a96f16458b411b7355bb31934 830c5872cf4236cd61bd3b1901425b24 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1839715834122993664 |