Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations

Bibliographic Details
Main Author: Paes, Rodrigo Almeida
Publication Date: 2014
Other Authors: Oliveira, Manoel Marques Evangelista de, Freitas, Dayvison Francis Saraiva, Valle, Antonio Carlos Francesconi do, Oliveira, Rosely Maria Zancopé, Galhardo, Maria Clara Gutierrez
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pntd.0003094
Download full: https://arca.fiocruz.br/handle/icict/10280
Summary: FAPERJ, Cnpq, PAPES, CAPES
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spelling Paes, Rodrigo AlmeidaOliveira, Manoel Marques Evangelista deFreitas, Dayvison Francis SaraivaValle, Antonio Carlos Francesconi doOliveira, Rosely Maria ZancopéGalhardo, Maria Clara Gutierrez2015-05-11T16:28:11Z2015-05-11T16:28:11Z2014PAES, Rodrigo Almeida et al. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations. Plos One, v. 8, n. 9, p.e3094, 2014.1932-6203https://arca.fiocruz.br/handle/icict/1028010.1371/journal.pntd.00030941932-6203FAPERJ, Cnpq, PAPES, CAPESFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Dermatologia Infecciosa. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Dermatologia Infecciosa. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Dermatologia Infecciosa. Rio de Janeiro, RJ, BrasilBackground: There have been several recent changes in the taxonomy of Sporothrix schenckii as well as new observations regarding the clinical aspects of sporotrichosis. In this study, we determined the identification of the Sporothrix species associated with both classic and unusual clinical aspects of sporotrichosis observed in the endemic area of sporotrichosis in Rio de Janeiro, Brazil. Methodology/Principal Findings: To verify whether S. brasiliensis is associated with clinical manifestations of sporotrichosis, a cross-sectional study was performed in which Sporothrix isolates from 50 patients with different clinical manifestations were analyzed and their isolates were studied by phenotypic and genotypic methods. Data from these patients revealed a distinct clinical picture and therapeutic response in infections caused by Sporothrix brasiliensis (n = 45) compared to patients with S. schenckii sensu stricto (n = 5). S. brasiliensis was associated with disseminated cutaneous infection without underlying disease, hypersensitivity reactions, and mucosal infection, whereas patients with S. schenckii presented with less severe and more often localized disease, similar to the majority of previously described sporotrichosis cases. Interestingly, S. brasiliensisinfected patients overall required shorter durations of itraconazole (median 16 weeks) compared to the individuals with S. schenckii (median 24 weeks). Conclusions/Significance: These findings suggest that Sporothrix species are linked to different clinical manifestations of sporotrichosis and that S. brasiliensis is effectively treated with oral itraconazole.engPublic Library of ScienceSporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSporothrixBrazil/ethnologySporotrichosisMycologySporothrixBrasil/etnologiaEsporotricoseMicologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://arca.fiocruz.br/bitstreams/dc38d258-81bf-4853-9fe7-4daf525a3c77/downloadafbdf7d7a9bcf771a1cc7edf5f618413MD51falseAnonymousREADORIGINALSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdfSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdfapplication/pdf3529297https://arca.fiocruz.br/bitstreams/75e9b756-fb1b-41b5-a415-616eaa95a23a/download58ad9775b03ce23302e91db1323da229MD52trueAnonymousREADTEXTSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdf.txtSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdf.txtExtracted texttext/plain43177https://arca.fiocruz.br/bitstreams/135c9d1a-42d2-41ce-aac9-65950c441bb4/download20fd227a96f16458b411b7355bb31934MD57falseAnonymousREADTHUMBNAILSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdf.jpgSporotrichosis in Rio de Janeiro, Brazil Sporothrix brasiliensis Is Associated with Atypical Clinical Presentations.pdf.jpgGenerated Thumbnailimage/jpeg6612https://arca.fiocruz.br/bitstreams/7f526b81-bea7-44e4-a5d8-28722a2c20df/download830c5872cf4236cd61bd3b1901425b24MD58falseAnonymousREADicict/102802025-07-29 18:24:34.769open.accessoai:arca.fiocruz.br:icict/10280https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T21:24:34Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
title Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
spellingShingle Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
Paes, Rodrigo Almeida
Sporothrix
Brazil/ethnology
Sporotrichosis
Mycology
Sporothrix
Brasil/etnologia
Esporotricose
Micologia
title_short Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
title_full Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
title_fullStr Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
title_full_unstemmed Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
title_sort Sporotrichosis in Rio de Janeiro, Brazil: sporothrix brasiliensis is associated with atypical clinical presentations
author Paes, Rodrigo Almeida
author_facet Paes, Rodrigo Almeida
Oliveira, Manoel Marques Evangelista de
Freitas, Dayvison Francis Saraiva
Valle, Antonio Carlos Francesconi do
Oliveira, Rosely Maria Zancopé
Galhardo, Maria Clara Gutierrez
author_role author
author2 Oliveira, Manoel Marques Evangelista de
Freitas, Dayvison Francis Saraiva
Valle, Antonio Carlos Francesconi do
Oliveira, Rosely Maria Zancopé
Galhardo, Maria Clara Gutierrez
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Paes, Rodrigo Almeida
Oliveira, Manoel Marques Evangelista de
Freitas, Dayvison Francis Saraiva
Valle, Antonio Carlos Francesconi do
Oliveira, Rosely Maria Zancopé
Galhardo, Maria Clara Gutierrez
dc.subject.en.none.fl_str_mv Sporothrix
Brazil/ethnology
Sporotrichosis
Mycology
topic Sporothrix
Brazil/ethnology
Sporotrichosis
Mycology
Sporothrix
Brasil/etnologia
Esporotricose
Micologia
dc.subject.decs.none.fl_str_mv Sporothrix
Brasil/etnologia
Esporotricose
Micologia
description FAPERJ, Cnpq, PAPES, CAPES
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-11T16:28:11Z
dc.date.available.fl_str_mv 2015-05-11T16:28:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAES, Rodrigo Almeida et al. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations. Plos One, v. 8, n. 9, p.e3094, 2014.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/10280
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0003094
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv PAES, Rodrigo Almeida et al. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations. Plos One, v. 8, n. 9, p.e3094, 2014.
1932-6203
10.1371/journal.pntd.0003094
url https://arca.fiocruz.br/handle/icict/10280
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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