Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil

Bibliographic Details
Main Author: Riccio, Evelyn Kety Pratt
Publication Date: 2005
Other Authors: Zalis, Mariano Gustavo, Guedes, Helena Cristina Balthazar, Banic, Dalma Maria, Souza, José Maria de, Alecrim, Wilson, Camus, Daniel, Ribeiro, Cláudio Tadeu Daniel, Cruz, Maria de Fátima Ferreira da
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/s0074-02762005000100009
Download full: https://arca.fiocruz.br/handle/icict/36905
Summary: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da OMS para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.
id CRUZ_31dff6548a34352f1da9c94d7376e0a3
oai_identifier_str oai:arca.fiocruz.br:icict/36905
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Riccio, Evelyn Kety PrattZalis, Mariano GustavoGuedes, Helena Cristina BalthazarBanic, Dalma MariaSouza, José Maria deAlecrim, WilsonCamus, DanielRibeiro, Cláudio Tadeu DanielCruz, Maria de Fátima Ferreira da2019-11-06T16:04:49Z2019-11-06T16:04:49Z2005RICCIO, Evelyn Kety Pratt et al. Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 47-49, Feb. 2005.0074-0276https://arca.fiocruz.br/handle/icict/3690510.1590/s0074-027620050001000091678-8060engFiocruz/IOCMaláriaPlasmodium falciparumPolimorfismoAntígeno rico serinoMalariaPlasmodium falciparumserine rich antigenPolymorphismGenetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da OMS para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da OMS para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Fundação de Medicina Tropical do Amazonas. Centro Universitário Nilton Lins. Manaus, AM, Brasil.Université de Lille. Laboratoire de Parasitologie-Mycologie. Faculte de Medecine. Lille, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da OMS para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da OMS para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.In this work we investigated the frequency of polymorphism in exon II of the gene encoding most of the amino-terminal region of the serine rich antigen (SERA) in Plasmodium falciparum field samples. The blood samples were collected from P. falciparum infected individuals in three areas of the Brazilian Amazon. Two fragments have been characterized by polymerase chain reaction: one of 175 bp corresponding to the repeat region with 5 octamer units and one other of 199 bp related to the 6 repeat octamer units of SERA protein. The 199 bp fragment was the predominant one in all the studied areas. The higher frequency of this fragment has not been described before and could be explained by an immunological selection of the plasmodial population in the infected individuals under study. Since repeat motifs in the amino-terminal region of SERA contain epitopes recognized by parasite-inhibitor antibodies, data reported here suggest that the analysis of the polymorphism of P. falciparum isolates in different geographical areas is a preliminary stage before the final drawing of an universal vaccine against malaria can be reached.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/9b9d8a2c-9a5a-4cec-b41c-819b9ac41a88/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALEvelynRiccio-MariaFatimaCruz_etal_IOC_2005.pdfEvelynRiccio-MariaFatimaCruz_etal_IOC_2005.pdfapplication/pdf35558https://arca.fiocruz.br/bitstreams/816a2344-fcf8-462c-b67e-beb09fed0286/downloadf718ec1f06654849bcf38ff6c2af5416MD52trueAnonymousREADTEXTEvelynRiccio-MariaFatimaCruz_etal_IOC_2005.pdf.txtEvelynRiccio-MariaFatimaCruz_etal_IOC_2005.pdf.txtExtracted texttext/plain16778https://arca.fiocruz.br/bitstreams/c1c8a8f9-fba5-47fd-9de5-344b679d3c57/download6aaa5abc9c3beb9a028df70413367dcaMD57falseAnonymousREADTHUMBNAILEvelynRiccio-MariaFatimaCruz_etal_IOC_2005.pdf.jpgEvelynRiccio-MariaFatimaCruz_etal_IOC_2005.pdf.jpgGenerated Thumbnailimage/jpeg6216https://arca.fiocruz.br/bitstreams/3c654899-ff7d-4c9e-adca-c1106213e752/download4b8e6bc2e17d95430b473e6085321b94MD58falseAnonymousREADicict/369052025-07-31 13:23:30.724open.accessoai:arca.fiocruz.br:icict/36905https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-31T16:23:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
title Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
spellingShingle Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
Riccio, Evelyn Kety Pratt
Malária
Plasmodium falciparum
Polimorfismo
Antígeno rico serino
Malaria
Plasmodium falciparum
serine rich antigen
Polymorphism
title_short Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
title_full Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
title_fullStr Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
title_full_unstemmed Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
title_sort Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil
author Riccio, Evelyn Kety Pratt
author_facet Riccio, Evelyn Kety Pratt
Zalis, Mariano Gustavo
Guedes, Helena Cristina Balthazar
Banic, Dalma Maria
Souza, José Maria de
Alecrim, Wilson
Camus, Daniel
Ribeiro, Cláudio Tadeu Daniel
Cruz, Maria de Fátima Ferreira da
author_role author
author2 Zalis, Mariano Gustavo
Guedes, Helena Cristina Balthazar
Banic, Dalma Maria
Souza, José Maria de
Alecrim, Wilson
Camus, Daniel
Ribeiro, Cláudio Tadeu Daniel
Cruz, Maria de Fátima Ferreira da
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Riccio, Evelyn Kety Pratt
Zalis, Mariano Gustavo
Guedes, Helena Cristina Balthazar
Banic, Dalma Maria
Souza, José Maria de
Alecrim, Wilson
Camus, Daniel
Ribeiro, Cláudio Tadeu Daniel
Cruz, Maria de Fátima Ferreira da
dc.subject.other.none.fl_str_mv Malária
Plasmodium falciparum
Polimorfismo
Antígeno rico serino
topic Malária
Plasmodium falciparum
Polimorfismo
Antígeno rico serino
Malaria
Plasmodium falciparum
serine rich antigen
Polymorphism
dc.subject.en.none.fl_str_mv Malaria
Plasmodium falciparum
serine rich antigen
Polymorphism
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da OMS para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Departamento de Imunologia. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-11-06T16:04:49Z
dc.date.available.fl_str_mv 2019-11-06T16:04:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RICCIO, Evelyn Kety Pratt et al. Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 47-49, Feb. 2005.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/36905
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762005000100009
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv RICCIO, Evelyn Kety Pratt et al. Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 47-49, Feb. 2005.
0074-0276
10.1590/s0074-02762005000100009
1678-8060
url https://arca.fiocruz.br/handle/icict/36905
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/9b9d8a2c-9a5a-4cec-b41c-819b9ac41a88/download
https://arca.fiocruz.br/bitstreams/816a2344-fcf8-462c-b67e-beb09fed0286/download
https://arca.fiocruz.br/bitstreams/c1c8a8f9-fba5-47fd-9de5-344b679d3c57/download
https://arca.fiocruz.br/bitstreams/3c654899-ff7d-4c9e-adca-c1106213e752/download
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
f718ec1f06654849bcf38ff6c2af5416
6aaa5abc9c3beb9a028df70413367dca
4b8e6bc2e17d95430b473e6085321b94
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1839715852928155648

Similar Items