Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi

Bibliographic Details
Main Author: Abreu, Raquel Tropia de
Publication Date: 2011
Other Authors: Carvalho, Maria das Graças, Carneiro, Cláudia Martins, Giunchetti, Rodolfo Cordeiro, Carvalho, Andréa Teixeira, Martins Filho, Olindo Assis, Vital, Wendel Coura, Oliveira, Rodrigo Corrêa, Reis, Alexandre Barbosa
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pone.0018873
Download full: https://arca.fiocruz.br/handle/icict/8663
Summary: Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Análises Clínicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil.
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spelling Abreu, Raquel Tropia deCarvalho, Maria das GraçasCarneiro, Cláudia MartinsGiunchetti, Rodolfo CordeiroCarvalho, Andréa TeixeiraMartins Filho, Olindo AssisVital, Wendel CouraOliveira, Rodrigo CorrêaReis, Alexandre Barbosa2014-10-23T11:01:30Z2014-10-23T11:01:30Z2011ABREU, Raquel Trópia de et al. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi. PLoS One, v. 6, n. 5, p. 1-9, 2011.1932-6203https://arca.fiocruz.br/handle/icict/866310.1371/journal.pone.0018873engPublic Library of ScienceInfluence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Análises Clínicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Laboratório de Hematologia Clínica. Belo Horizonte, MG, Brazil.Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Análises Clínicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil.Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil.Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Análises Clínicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Análises Clínicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Background: The bone marrow is considered to be an important storage of parasites in Leishmania-infected dogs, although little is known about cellular genesis in this organ during canine visceral leishmaniasis (CVL). Methodology/Principal Findings: The aim of the present study was to evaluate changes in erythropoiesis and leucopoiesis in bone marrow aspirates from dogs naturally infected with Leishmania chagasi and presenting different clinical statuses and bone marrow parasite densities. The evolution of CVL from asymptomatic to symptomatic status was accompanied by increasing parasite density in the bone marrow. The impact of bone marrow parasite density on cellularity was similar in dogs at different clinical stages, with animals in the high parasite density group. Erythroid and eosinophilic hypoplasia, proliferation of neutrophilic precursor cells and significant increases in lymphocytes and plasma cell numbers were the major alterations observed. Differential bone marrow cell counts revealed increases in the myeloid:erythroid ratio associated to increased numbers of granulopoietic cells in the different clinical groups compared with non-infected dogs. Conclusions: Analysis of the data obtained indicated that the assessment of bone marrow constitutes an additional and useful tool by which to elaborate a prognosis for CVL.Bone Marrow Cells/parasitologyErythropoiesis/physiologyLeishmania/pathogenicityLeishmaniasis/parasitologyLeukopoiesis/physiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://arca.fiocruz.br/bitstreams/9947fb53-337f-4e7c-a4da-f5090babed07/download7d48279ffeed55da8dfe2f8e81f3b81fMD51falseAnonymousREADORIGINAL. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi.pdf. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi.pdfapplication/pdf638648https://arca.fiocruz.br/bitstreams/3fb813d3-bff0-4f2e-81fa-76ebd4bd5b32/download267a7287c75fcd9e91c0d93983c4c4a7MD52trueAnonymousREADTEXT. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi.pdf.txt. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi.pdf.txtExtracted texttext/plain43700https://arca.fiocruz.br/bitstreams/2a31ffb1-14ac-4734-a380-181832a37aa2/downloadb5bc51bba01b766138cc7648fe6a8eebMD55falseAnonymousREADTHUMBNAIL. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi.pdf.jpg. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi.pdf.jpgGenerated Thumbnailimage/jpeg6649https://arca.fiocruz.br/bitstreams/71083c64-b505-40e6-8ed7-558dcaf6d01e/download0104287bd31d24bd397b2618b8500841MD56falseAnonymousREADicict/86632025-07-30 02:43:25.01open.accessoai:arca.fiocruz.br:icict/8663https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T05:43:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)falseTElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4K
dc.title.none.fl_str_mv Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
title Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
spellingShingle Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
Abreu, Raquel Tropia de
Bone Marrow Cells/parasitology
Erythropoiesis/physiology
Leishmania/pathogenicity
Leishmaniasis/parasitology
Leukopoiesis/physiology
title_short Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
title_full Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
title_fullStr Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
title_full_unstemmed Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
title_sort Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi
author Abreu, Raquel Tropia de
author_facet Abreu, Raquel Tropia de
Carvalho, Maria das Graças
Carneiro, Cláudia Martins
Giunchetti, Rodolfo Cordeiro
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Vital, Wendel Coura
Oliveira, Rodrigo Corrêa
Reis, Alexandre Barbosa
author_role author
author2 Carvalho, Maria das Graças
Carneiro, Cláudia Martins
Giunchetti, Rodolfo Cordeiro
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Vital, Wendel Coura
Oliveira, Rodrigo Corrêa
Reis, Alexandre Barbosa
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Abreu, Raquel Tropia de
Carvalho, Maria das Graças
Carneiro, Cláudia Martins
Giunchetti, Rodolfo Cordeiro
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Vital, Wendel Coura
Oliveira, Rodrigo Corrêa
Reis, Alexandre Barbosa
dc.subject.en.none.fl_str_mv Bone Marrow Cells/parasitology
Erythropoiesis/physiology
Leishmania/pathogenicity
Leishmaniasis/parasitology
Leukopoiesis/physiology
topic Bone Marrow Cells/parasitology
Erythropoiesis/physiology
Leishmania/pathogenicity
Leishmaniasis/parasitology
Leukopoiesis/physiology
description Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Departamento de Análises Clínicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-10-23T11:01:30Z
dc.date.available.fl_str_mv 2014-10-23T11:01:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ABREU, Raquel Trópia de et al. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi. PLoS One, v. 6, n. 5, p. 1-9, 2011.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/8663
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0018873
identifier_str_mv ABREU, Raquel Trópia de et al. Influence of Clinical Status and Parasite Load on Erythropoiesis and Leucopoiesis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi. PLoS One, v. 6, n. 5, p. 1-9, 2011.
1932-6203
10.1371/journal.pone.0018873
url https://arca.fiocruz.br/handle/icict/8663
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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