Phylogeography of the 2013 urban outbreak of dengue virus in Guarujá, São Paulo.

• Ano de defesa: 2014
• Autor(a) principal: Arenas, Christian Julian Villabona
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: eng
• Instituição de defesa: Biblioteca Digitais de Teses e Dissertações da USP
• Palavras-chave em Português: Dengue vírus; Diversidade genética; Epidemiologia; Epidemiology; Evolução molecular; Filogenia; Filogeografia; Genetic diversity; Molecular evolution; Phylogeny; Phylogeography; Vírus da dengue
• Link de acesso: http://www.teses.usp.br/teses/disponiveis/42/42132/tde-24022015-102317/

Dengue virus type 1 (DENV-1) was introduced in Brazil in 1986 and caused several epidemics. The first autochthonous cases of DENV-2 and DENV-3 were detected respectively in 1990 and 2000. Since then, the viruses have spread throughout Brazil and became endemic in most areas infested with Aedes aegypti. DENV-4 was isolated for the first time in 1982 in a focal epidemic in the northwestern region of the Brazilian Amazon. Later, in 2008, this serotype emerged as an important pathogen during outbreaks. The study of the historical processes that may be responsible for the contemporary geographic distributions of viruses is critical to understand viral epidemiology. However, those processes in urban scales are not well understood. 2013 was one of the worst years for dengue in the Brazils history, with 1.4 million cases, including 6,969 severe cases and 545 deaths. This project aimed to understand the dynamics of evolutionary change, origins and distributions of different viral strains in an urban setting during 2013. We expect this study to provide new perspectives for viral control.