Histological response to endodontic treatment in one versus two-visit: a systematic review of animal studies

• Ano de defesa: 2023
• Autor(a) principal: Oliveira Neto, Raimundo Sales de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: eng
• Instituição de defesa: Biblioteca Digitais de Teses e Dissertações da USP
• Palavras-chave em Português: Cicatrização; Hidróxido de cálcio; Tratamento do canal radicular
• Link de acesso: https://www.teses.usp.br/teses/disponiveis/25/25147/tde-17012024-174621/

There is no consensus in the literature regarding the need for intracanal medication in the endodontic treatment of teeth with apical periodontitis. The aim of this study is to conduct a systematic review of animal studies that compared, at the histological level, the characteristics of inflammatory infiltrate, periodontal ligament thickness, incidence of biological apical sealing, mineralized tissue resorption, and presence of microorganisms after endodontic treatment of teeth with apical periodontitis performed in one or two visits. The studies were collected from PubMed/MEDLINE, LILACS, EMBASE, Livivo, SciELO, Web of Science, Scopus, Cochrane Library, as well as manual and gray literature searches. Animal studies evaluating histological characteristics after endodontic treatment of teeth with apical periodontitis in one or two visits were included. Risk of bias assessment of the included studies was performed using the SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) tool. Data synthesis of included studies with quantitative data was conducted, and meta-analysis was performed using the Comprehensive Meta-Analysis software, employing a random-effects model and Odds ratio (OR). Eighteen studies met the inclusion criteria (Kappa=0.891). Meta-analyses indicated effect sizes for intensity of inflammatory infiltrate of 0.055 (95% CI: 0.020-0.148; p<0.001); periodontal ligament thickness effect size of 0.256 (95% CI: 0.134-0.487; p<0.001); dentin resorption effect size of 0.130 (95% CI: 0.015-1.141; p=0.066); cementum resorption effect size of 0.071 (95% CI: 0.015-0.325; p=0.001); bone resorption effect size of 0.014 (95% CI: 0.002-0.130; p<0.001); mineralized tissue resorption effect size of 0.428 (95% CI: 0.110-1.671; p=0.222); biological apical sealing effect size of 0.131 (95% CI: 0.055-0.314; p<0.001); presence of microorganisms effect size of 0.103 (95% CI: 0.014-0.747; p=0.025). The use of calcium hydroxide-based intracanal medication between sessions resulted in better histopathological characteristics. This review was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42022340849.