In situ effect of a proanthocyanidin mouthrinse on dentin submitted to erosion

• Ano de defesa: 2017
• Autor(a) principal: Cardoso, Fabrícia
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: eng
• Instituição de defesa: Biblioteca Digitais de Teses e Dissertações da USP
• Palavras-chave em Português: Dentin; Dentina; Desgaste dentário; Erosão; Erosion; Proanthocyanidin; Proantocianidina; Tooth wear
• Link de acesso: http://www.teses.usp.br/teses/disponiveis/25/25148/tde-28062018-170727/

The organic matrix is of great importance in the process of loss of dental tissue because it functions as a barrier that prevents the diffusion of the acids to the tissues. For its degradation to be avoided, some agents have been tested in an attempt to inhibit the MMPs, the enzymes responsible for this process. Proanthocyanidin has been shown to be efficient in inhibiting these enzymes and therefore the aim of this study in situ was to evaluate the protective effect of a mouthrinse based on proanthocyanidin applied on the dentin submitted to erosion. Seven volunteers wore 2 palatal devices in each phase. The groups under study were: First Phase/ G1 - Erosive challenge with acid drink (Coca-cola®) before dentin treatement with 10% proanthocyanidin mouthrinse (neutralized to pH 7.0, Experimental group 1), G2 - Erosive challenge with acid drink (Coca-cola®) before dentin treatement with 10% proanthocyanidin mouthrinse (without neutralization, pH 3.0, Experimental group 2). Second Phase/ G3 - Erosive challenge with acid drink (Coca-cola®) before dentin treatement with 0.12% Chlorhexidine mouthrinse (pH 7.0, Positive control group), G4 - Erosive challenge with acid drink (Coca-cola®) with no previous treatment (Negative control group). Treatments with different mouthrinses were applied once after the second erosive challenge, for 5 minutes. Volunteers continuously wore the oral appliance and for the erosive cycling, each device was immersed into the 32 ml of acid beverage, 3 times a day for 5 minutes during 5 days. Profilometry was used to quantify the dentin loss (m). Data were analyzed by Repeated measures ANOVA followed by LSD Fisherss test (p<0.05). G1 (1.17a ± 0.69) and G3 (1.22a ± 0.25) showed significant lower wear values with no statistical difference between them. There was also no significant differences between G2 (2.99b ± 1.15) and G4 (2.29b ± 1.13) resulting in more wear when compared to others groups. This study suggest that 10% neutralized proanthocyanidin mouthrinse could be a good strategy to diminish dentin wear progression.