Detalhes bibliográficos
| Ano de defesa: |
2007 |
| Autor(a) principal: |
Roman, Maria Cecília da Silveira |
| Orientador(a): |
Kinoshita, Ângela Mitie Otta
 |
| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
IASCJ - Universidade Sagrado Coração
|
| Programa de Pós-Graduação: |
Biologia Oral
|
| Departamento: |
Ciências da Saúde e Biológicas
|
| País: |
BR
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://localhost:8080/tede/handle/tede/148
|
Resumo: |
The pathologies related to articular cartilage injuries are frequently associated to the difficulties of complete regeneration of the hyaline cartilage that can develop articular illness. The evolution of this degenerative pathology causes the lost of movements. Many procedures have been developed and used to the treatment of these lesions. The low intensity laser is one of them. This technology has been used for treatment of harmful effects of inflammation as well as to accelerate the tissue regeneration in the injuries region. So, the subject of this work is to verify the effect of low intensity laser on the articular tissues (cartilage, fibrous tissue and bone trabeculae) after surgical injury and later stimulation. An experimental study in animal model was developed. 42 males Albinus wistar rats, with about 200 to 250g and 3 months old were used. The rats were distributed in 3 groups with 14 animals and each one was subdivided in 2 groups named stimulated group (SG) and control group (CG). Each animal were submitted the surgical injury with 2mm of diameter in the articular cartilage of right knee with dentistric drill. The SG group was treated with Arsenieto of Galio (GaAs) laser radiation; wavelength of 904nm, with a dose of 3J/cm2, through three points of application with 30s each (total 90s) for 10 successive days. The first group (SG and CG) was euthanized 14 days after surgery; the second after 28 days and the last, at 56 days. The experimental procedures were made at Centro Universitário Católico Salesiano Auxilium de Lins-SP bioterio. The histologycal and histometric analyses were made at Universidade do Sagrado Coração de Bauru SP. The evaluation of the results was made by histological and histometric comparative analysis between SG and CG for each period. The mean comparison was made by Tukey test with significance level of 0.05. The histometric results shows that the fibrous tissue growth was more effective in the SG after 28 days (65.4 ± 0.8 and 63.8 ± 0.4) and 56 days (66.2 ± 1.0 and 63.1 ± 0.7) in comparison with control group. The presence of bone trabeculae is higher in stimulated group at 14 period (18.4 ± 1.1 and 12.2 ± 0.7) and in the control group on the others periods (20.9 ± 0.5 and 24.1 ± 1.3) and (22.7 ± 0.8 and 26.8 ± 0.5) 28 and 56 days respectively. The fraction of cartilage presents differences statistically significant between the groups just on 14 days period and in the control group this fraction is higher (16.5 ± 0.7 and 24.9 ± 1.4). The histometric results indicate that the use of GaAs low intensity laser, in this dose, has effect on the tissue regeneration. |
