Alterações reprodutivas em cabras com doença de depósito lisossomal

Detalhes bibliográficos
Ano de defesa: 2018
Autor(a) principal: LIMA, Dayane Dias Coutinho Cavalcanti de lattes
Orientador(a): MENDONÇA, Fábio de Souza
Banca de defesa: AGUIAR FILHO, Cristiano Rocha de, SOUZA, Francisco de Assis Leite, ALBUQUERQUE, Samuel Salgado Cavalcanti de, ALMEIDA, Valdir Morais de
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal Rural de Pernambuco
Programa de Pós-Graduação: Programa de Pós-Graduação em Ciência Veterinária
Departamento: Departamento de Medicina Veterinária
País: Brasil
Palavras-chave em Português:
Área do conhecimento CNPq:
Link de acesso: http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/7679
Resumo: The objective of this study was to characterize reproductive failures in goats with lysosomal deposit disease induced by the consumption of Ipomoea carnea subsp. fistulosa, using six goat females, divided in control group and test group, formed by two and four animals, respectively. The test group females were feed with commercial ration mixed with I. carnea, containing 0.02% swainsonine at a dose of 2 g / kg of Live Weight for 60 days. Clinical and neurological examinations were performed using the Head Raising Test and Stand up Test. The reproductive functions were evaluated through vaginal cytology, laparoscopic evaluations of the ovaries, histopathological analyzes of the uterus, uterine tubes, ovaries, pituitary, thyroid, encephalon, pancreas, kidneys and liver were performed, as well as serum progesterone through ELISA. The progesterone concentrations were analyzed by the SAEG 7.0 program, applying analysis of variance and regression. Reproductive failures were observed after 25 days of initiation of the plant supply and did not present with nerve signals characteristic of lysosomal deposit disease. These were only manifested after 40 days of ogram, applying analysis of variance and regression. Reproductive failures were observed after 25 days of initiation of the plant supply and did not present with nerve signals characteristic of lysosomal deposit disease. These were only manifested after 40 days of consumption of I. carnea. In the adaptation phase, all females (test group and control group) presented estrus, ovulation and cytology compatible with the phases of the cycle. From 21 days of experiment, the females of the test group showed no estrus behavior. Analysis of the vaginal smears showed changes from the second cycle evaluated, which consisted of cellularity incompatible with the estrous cycle phase, differing from the control females. Laparoscopy showed no ovulation during the experimental period, with observation of follicular recruitment. Serum progesterone concentrations of test and control goats did not differ from each other, taking into account the dosages throughout the experimental period. In the evaluation of the period corresponding to the last two cycles, there was a significant difference. Vacuolation lesions were observed in Purkinje neurons, follicular thyroid cells, pancreatic epithelial cells and hepatocytes. Vacuolation and degeneration of the teak cells were observed. It was concluded that goats intoxicated by Ipomoea carnea subsp. fistulosa, even in small amounts of the plant, may present reproductive failures. Lysosomal storage disease due to swainsonine intake, in addition to the nervous system, also affects the reproduction of goat females, compromising the estrous cycle due to changes in the progesterone hormone profile, probably associated with cell lesions in the ovaries.