Análise químico-farmacêutica de preparações injetáveis de Aztreonam

Detalhes bibliográficos
Ano de defesa: 2014
Autor(a) principal: Figueiredo, Andressa Leme de [UNESP]
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual Paulista (Unesp)
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/11449/108733
Resumo: Aztreonam is a β-lactam antibiotic, synthetic, monocyclic with bactericidal activity against Gram-negative bacteria. It was discovered in 1978, and it was the first antibiotic of the monobactam family to be therapeutically approved. It can be used in the treatment of urinary tract infections, sepsis, meningitis, skin infections, such as wounds, ulcers, burns, intra-abdominal infections, such as peritonitis and cellulitis pelvic endometritis, and respiratory infections, such as cystic fibrosis. It is not absorbed orally and has a half-life of 1-6 hours and the bioavailability of almost 100% for intramuscularly administration. Regarding the mechanism of action, aztreonam, like other β-lactam antibiotics, has the ability to inhibit bacterial growth by interfering at a specific stage of the cell wall synthesis. Despite being a substance is highly studied and researched in relation to its antimicrobial activity, pharmacokinetics and pharmacodynamics, analytical methods in biological fluids, there are few studies in the literature regarding the development of analytical methodology for aztreonam lyophilized powder for injectable solution. Thus, this study aimed to develop new analytical methods for the analysis of aztreonam in lyophilized powder for injectable solution, which have the lowest impact on the environment as possible and that be more convenient, safer for operators and more economical than the analytical methodologies already described. Aztreonam chemical reference and sample were analyzed qualitatively about the organoleptic characteristics, weight, melting point, moisture, sulphated ash, thin layer chromatography indicative of stability, ultraviolet spectrophotometry, infrared spectrophotometry and high performance liquid chromatography. The developed methods were validated according national and international guidelines. It was determined quantitatively by ultraviolet spectrophotometry at 292 nm, using water as a solvent, with ...