Efeito da endogamia na seleção genômica em populções simuladas de aves poedeiras

• Ano de defesa: 2014
• Autor(a) principal: Nascimento, Guilherme Batista do [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Ave poedeira; Genômica; Genoma; Endogamia; Genetica animal; Genomics
• Link de acesso: http://hdl.handle.net/11449/110560

The objective of this study was to evaluate the prediction accuracy of genomic breeding values for traits of different heritability in simulated populations with different inbreeding. Phenotypic and genotypic data were simulated based on the population structure of an experimental population of White Leghorn hens at Embrapa Suínos e Aves. The phenotypes and genotypes were simulated for the rate of total egg production (PTO) and egg weight to 32 weeks of age (PO) with heritability of 0.15 and 0.37, respectively. The historical population was simulated to generate linkage disequilibrium in the population. Three scenarios in recent populations were simulated for each trait: REC1, REC2 and REC3 to maximize inbreeding, minimize inbreeding and random mating, respectively. The animals were selected based on the largest breeding values along 10 generations. The genome of the birds was simulated with eight macro-chromosomes and 19 micro-chromosomes with 3.747 QTL randomly distributed and 49.978 SNPs markers evenly spaced along the 958 cM. Recombination, random drift and recurrent mutation were simulated in order to generate genetic variability. The linkage disequilibrium (LD), effective population (Ne) and genetic trends were calculated for all scenarios. Each recent population was divided in training and validation sets In order to predict the genomic breeding values. The training set included the genotypes and phenotypes of 960 animals, which had higher breeding values’ accuracy. The validation set had 1120 animals of the last generation of the recent population. The average inbreeding ranged from 0.06 ± 0.30 to 0.22 ± 0.12 for PTO and 0.05 ± 0.03 to 0.20 ± 0.12 for PO. The REC1 populations had higher inbreeding along generations compared, both for PTO and PO, compared to REC2 and REC 3, and consequently higher level of LD. The highest accuracy for PTO and PO were ...