Equação de Fokker-Planck e enovelamento de proteínas

• Ano de defesa: 2015
• Autor(a) principal: Polotto, Franciele [UNESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Biologia molecular; Biofísica; Proteinas globulares; Fokker-Planck, Equação de; Dobramento de proteína; Equações diferenciais estocasticas
• Link de acesso: http://hdl.handle.net/11449/127917; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/01-09-2015/000844436.pdf

This work is presents a study of the Fokker-Planck equation using a polynomial function to simulate the free energy which is obtained from a fit of the values that emerge from computer simulations. Through a semi-analytical description, the Fokker-Planck equation is solved using its relationship with an equation of Schrödinger-type. It is used the supersymmetric quantum mechanics and the variational method. From the study of the probability distribution obtained for different profiles of free energy, it is possible to analyze the evolution of the system by varying the initial conditions and obtaining the characteristic time of the process