Lactato sanguíneo em cães com insuficiência cardíaca congestiva decorrente de degeneração valvular mitral

Detalhes bibliográficos
Ano de defesa: 2014
Autor(a) principal: Silva Filho, Jorge Cardoso da [UNESP]
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual Paulista (Unesp)
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/11449/121882
Resumo: This study was aimed at characterizing the concentration of serum lactate in dogs with varying stages mitral valve degeneration, searching for a correlation between such parameter and the electrocardiographic, radiographic, echocardiographic and blood pressure data, as to investigate its value as a diagnostic indicator of tissue hypoperfusion in dogs with heart failure. The analyses of the serum concentration of lactate disclosed results estatistically higher in dogs belonging to CHF class II as compared to control animals, as well as between class IIIa dogs as compared to controls, class Ia, and class Ib dogs. However, the results of class II dogs were similar to those of classes Ia and Ib animals. Also, no difference was documented between the results of classes II and IIIa dogs. A positive correlation was identified between serum lactate concentration and the left ventricular internal diameter, fractional shortening, and left atrium-to-aorta ratio. A positive correlation was also observed between serum lactate and mean heart rate, VHS, and P wave amplitude. A negative correlation was documented between serum lactate and systolic blood pressure. A larger area under the ROC curve was disclosed for the jugular lactate, which showed the concentration of 3,25 mmol/L to provide the highest sensibility and specificity in differentiating healthy dogs from those presenting CHF. The results support that blood lactate increases as heart failure worsens