Estudo fitoquímico e propriedades biológicas da Dipteryx alata Vogel (baru)

• Ano de defesa: 2014
• Autor(a) principal: Sanchez, Rodolfo Marcchiori [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Química vegetal; Plantas dos cerrados; Antioxidantes; Agentes anti-infecciosos; Botanical chemistry
• Link de acesso: http://hdl.handle.net/11449/123176; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/22-04-2015/000824410.pdf

Due to the importance of the cerrado biome, including the maintenance of other interconnected biomes in recent decade’s researchers from different fields have proposed alternative use of the cerrado species as a way to preserve the local fauna and flora. One way to help the preservation of species is the study of the medicinal properties of plants of this biome used in traditional medicine. The objective of these studies is to confirm the therapeutic potential and the toxicity of these plants used in traditional local medicine as well as studying the medicinal potential of plants yet to be investigated. The specie Dipteryx alata Vogel (baru) is a native species of the cerrado with great nutritional and pharmacological potential to be investigated, because according to traditional medicine it is used to combat bronchitis, diarrhea, dysentery, pain, sore throat, flu, snakebite, cough and as cicatrizant, however, only the activity against snakebite has been scientifically proven. Therefore, trying to combine the nutritional value of baru fruits pulp to the potential therapeutic effect, studies on the determination of phytochemicals present were performed to guide studies on possible biological properties valuing the fruit as a nutraceutical food in areas of occurrence of the plant that show high negligible diseases indices. The results of the phytochemical studies showed the presence of alkaloids, tannins, flavonoids, saponins and cardiotonic glycosides in considerable amounts and anthraquinones at low concentration. The presence of these phytochemicals has given support for conducting tests to determine the antiparasitic potential. Antimicrobial activity was also evaluated due to the medicinal use of the plant for the urinary tract infections. In addition, the cytotoxicity of the pulp was also evaluated on LLC- MK 2 cells to support the safe use of the fruit. Antimicrobial assays were performed using the bacterial strains Proteus sp., E. ...