Parâmetros genéticos para integridade óssea do fêmur e estudo da associação dos genes runx2 e tnfs11 em frangos de corte

• Ano de defesa: 2015
• Autor(a) principal: Grupioni, Natalia Vinhal [UNESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Frango de corte; Genes; Estimativa de parametro; Femur; Genetica animal; Animal genetics
• Link de acesso: http://hdl.handle.net/11449/123937; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/08-06-2015/000834610.pdf

In the broiler breeding programs, the broilers are selected primarily for performance and carcass traits, resulting in changes in the size, shape and function of organs which implies important physiological changes during the development of the broilers. Intense selection of broilers resulted in locomotors problems, decreased bone strength of animals and increased mortality. Thus, molecular screening techniques began to be used in order to identify candidate genes to assist in the selection of related traits to bone disorders. The objective of this study was estimate genetic parameters for traits related to femoral integrity bone and weight at 42 days and association study of RUNX2 (Runt-related transcription factor 2) and TNFSF11 (Tumor necrosis factor (ligand) superfamily, member 11) genes with economical traits in broilers in order to provide support for the broiler breeding program and direct the selection process to reduce problems related to bone disorders. Estimates of genetic parameters were obtained for traits associated with the femur bone integrity and weight at 42 days of age by the restricted maximum likelihood method using multi-trait animal model with the fixed group effect (sex and incubation), and the random effects and additives residuals. The investigation of polymorphisms in association RUNX2 genes and TNFSF11 and the association study of polymorphisms found and their respective SNPs (Nucleotide single polymorphism) of RUNX2 genes (SNP g.57.397A>G) and TNFSF11 (SNP g.14.614A> g) with the performance, carcass composition, parts and femoral bone integrity in order to evaluate the effects of these polymorphisms about this group of traits to maximum likelihood method. We used the TT reference population database with about 1,500 broilers belonging to Embrapa Swine and Poultry Breeding Program in Concordia/SC, Brazil. Heritability coefficients estimated for weight at 42 days of age (W42) and the related traits to ...