Efeito in vivo da deposição de filmes de DLC com e sem nanopartículas de prata sobre liga de titânio para utilização em próteses articulares

• Ano de defesa: 2015
• Autor(a) principal: Ankha, Milagros del Valle El Abras [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Prótese; Nanotecnologia; Transtornos da articulação temporomandibular; Osseointegração; Osseointegration
• Link de acesso: http://hdl.handle.net/11449/136771; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/28-03-2016/000860852.pdf

Hard coating materials to improve the biotribologic properties of joint prostheses have been the focus of research for some time. Various types of carbon films have been described, reporting failures and successes and also suggesting the need for more research. Because of that, the aim of this work was to evaluate the structural characteristics and biocompatibility of diamond-like carbon films with and without nano-particles of silver (DLC and DLC-Ag, respectively), applied by plasma (PECVD) on a titanium alloy (Ti-6Al-4V). Sixty samples of Ti-6Al-4V, were divided into three groups in which 20 were coated with DLC film, 20 with DLC-Ag and 20 without coating. After the structural characterization, samples were fixed bilaterally in the mandible angle of 20 rabbits of New Zealand race. After periods of 15 and 90 days the animals were euthanized and five samples per group were randomly assigned to postoperative characterization and five for qualitative and quantitative analysis of new bone formation. The data were treated statistically, using descriptive and inferential analysis, by ANOVA parametric test two factors for repeated measures and when necessary, the multiple comparison test of Tukey (p<0.05%). It has been found that the DLC and DLC-Ag films showed high electrical resistance and did not suffer significant changes in its Raman spectrum after periods of 15 and 90 days. Histological examination after 15 days showed proliferating immature bone trabeculae, from the preexisting bone in the direction of the sample and .and sometimes partially covering its surface. At 90 days it was difficult delineate the newly formed bone area of the preexisting. Mature and organized bone was seen within the interface, comprising almost its entirety, in most cases. This was observed in all groups, confirming the results obtained in the histomorphometric analysis, there was no statistically significant ...