Detalhes bibliográficos
Ano de defesa: |
2013 |
Autor(a) principal: |
Batista, Diego Fernando [UNESP] |
Orientador(a): |
Não Informado pela instituição |
Banca de defesa: |
Não Informado pela instituição |
Tipo de documento: |
Dissertação
|
Tipo de acesso: |
Acesso aberto |
Idioma: |
por |
Instituição de defesa: |
Universidade Estadual Paulista (Unesp)
|
Programa de Pós-Graduação: |
Não Informado pela instituição
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: |
|
Link de acesso: |
http://hdl.handle.net/11449/108619
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Resumo: |
The aim of our study was to evaluate the influence of the period of early physical activity on remodeling after infarction in rats by analysis of morphological, functional, biochemical, cellular and interstitial heart. Wistar rats were used, males, between 200 - 250g were subjected to experimental infarction. After 48 hours of the procedure, the surviving animals were randomly allocated into three groups: group S (n = 24): group of infarcted animals, group P (n = 24): group of infarcted animals exercised early; Group T (n = 24) : groups of infarcted animals exercised later. After 3 months of followup was conducted morphological and functional study of the following methods: isolated heart, echocardiography, histology and morphometry. Biochemical analysis was performed by the area of myocytes, infarct size and percentage of collagen in the cardiac tissue were assessed by spectrophotometry oxidative stress and energy metabolism. Statistical analysis was performed by ANOVA one-way, the significance level was 5%. Morphological assessed by echocardiogram showed that the animals in the late exercised had lower septal wall thickness that the group P (S = 1.69 ± 0.28, P = 1.81 ± 0.34, T = 1 , 46 ± 0.22, p = 0.041) and lower diastolic areas (S = 105 ± 12, P = 96 ± 23, T = 87 ± 11, p = 0.010) and systolic (S = 76 ± 8, P = 69 ± 8, T = 62 ± 9, p = 0.012) than the group S. In relation to functional variables assessed by echocardiography, the T group had higher shortening velocity of the posterior wall (PWSV) (S = 24 ± 4, P = 28 ± 6, T = 29 ± 3, p = 0.050) and A'média wave (S = 2.37 (2.25 to 3.25), P = 2.7 (2.5 to 3.0), T = 3.5 (3.5-4.4); p = 0.040) of the wave A 'Septal (S = 2.50 (2.0 to 3.25) P = 2.5 (2.12 to 3.0), T = 4.0 (3.12 - 4.0), p = 0.019) except IVRT / RR (S = 50.2 ± 10.7, P = 66.0 ± 10.7, T = 61.3 ± 9.4, p = 0.018) the P animals showed an improvement compared to the animals in group T. There were no differences in infarct ... |