Influência de uma superfície modificada por fluoretos na osseointegração de implantes dentais em ratos diabéticos

• Ano de defesa: 2013
• Autor(a) principal: Fontanari, Lucas Amaral [UNESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Implantes dentários; Fluoretos; Diabetes; Dental implants
• Link de acesso: http://hdl.handle.net/11449/108428

Pre-clinical and clinical studies have been showed that some systemic diseases like the diabetes mellitus may alter the bone repair process. At the oral cavity, the diabetes may be associated with poor osseointegration of dental implants and worsening of the prognosis of dental implants treatment. Thus, modifications on the dental implants surfaces that enhance the bone repair could help to offset the deleterious influences related to diabetes. The aim of this study was to evaluate, in diabetic rats, the influence of different implants surfaces on the osseointegration. A sample of 180 rats (90 for the biomechanical analysis and 90 for the histometric analysis) was randomly allocated in 3 groups of 60 rats each: Control Group (C): Healthy animals; Non-controlled diabetes Group (D): Animals with uncontrolled diabetes; Controlled Diabetes Group (DC): Animals with controlled diabetes. The diabetes was induced by injection of streptozotocin and it was controlled by injectios of insulin. After 4 weeks of the diabetes induction, all the animals received 1 implant in each tibia, one with a machined surface (M) and the other one with a fluoride surface modification. The animals were euthanized 2, 4 and 6 weeks after the implants placement. The biomechanical analysis was performed ex vivo by means of removal torque resistance, and the quality of the bone tissue formed around the implants was assessed by histometric analysis of bone / implant contact (BIC) and bone area between the threads of the implant (BAFO). The numerical data (Weight, Glicemic index, removal torque, BIC, and BAFO) were evaluated by the normality test of Shaprio-Wilk and the one-way Anova complemented by the Tukey´s test. All the statistical test were applied with a significance level of 5%. Regarding the biomechanical analysis, for the machined surface implants, the group D showed lower removal torque values (p <0.05) than the group C...