Estudo de possíveis correlações entre miastenia grave e exposiçao crônica a pesticidas em nosso meio

• Ano de defesa: 2015
• Autor(a) principal: Camargo, Abigail [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Miastenia grave; Doenças neuromusculares; Pesticidas - Efeito fisiológico; Pesticides - Physiological effect; Myasthenia gravis
• Link de acesso: http://hdl.handle.net/11449/126477; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/08-07-2015/000839732.pdf

In the São Paulo state is very common application of pesticides in agriculture without protective equipment, with great exposure of workers to the toxic agents, and domestic use of insecticides is also widespread. Neuromuscular transmission defects with myasthenia related to the organophosphate pesticides were demonstrated in human and animals. The chemical group of pyrethrins and pyrethroids has action on the peripheral nervous system of insects and humans. The aim of this study was to search correlations between Myasthenia Gravis and chronic exposure to pesticides in our geographic region. Questionnaires were applied on exposure to pesticides in 217 patients with clinical and EMG diagnosis of Myasthenia Gravis, 163 women and 54 men, aged from 14-84 years, seen in two medical services of UNESP and UNIFESP, and in 227 controls, 179 women and 48 men, aged from 17-78 years. Data were statistically analyzed by the Association Chi-square test. The statistical analysis of all patients exposed or not exposed suggested possible association of myasthenia gravis with chronic exposure to pesticides (p <0.0001)