Estudo de liberação de lamotrigina inserida em fibras de Ecovio®

• Ano de defesa: 2023
• Autor(a) principal: Cândido, Gabriela Braga Gomes
• Orientador(a): Dragunski, Douglas Cardoso
• Banca de defesa: Bittencourt, Paulo Rodrigo Stival , Menolli, Rafael Andrade , Dragunski, Douglas Cardoso
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual do Oeste do Paraná; Toledo
• Programa de Pós-Graduação: Programa de Pós-Graduação em Química
• Departamento: Centro de Engenharias e Ciências Exatas
• País: Brasil
• Palavras-chave em Português: Ecovio®; Lamotrigina; Eletrofiação; Liberação transdérmica de fármaco; Modelo cinético de liberação
• Palavras-chave em Inglês: Lamotrigine; Electrospinning; Transdermal drug delivery; Release kinetic model
• Área do conhecimento CNPq: CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: https://tede.unioeste.br/handle/tede/7557

Epilepsy is a disease caused by an alteration in auditory signals, which can cause fainting and muscle contractions. Thus, one of the medications indicated for the treatment of epileptic seizures is Lamotrigine, classified as class II in the biopharmaceutical classification system, as it has low solubility and high permeability in interstitial fluids. Currently, the pharmaceutical forms currently available for the treatment of epilepsy present high rates of drug interactions and new forms of drug release have been investigated, in which transdermal delivery systems have appeared with great prominence. Therefore, the present work aims to produce polymeric nanofibers using the electrospinning technique, incorporating the drug Lamotrigine into its structure. To this end, the experimental conditions for the production of fibers were evaluated, using the Ecovio® polymer mixture in order to obtain an alternative administration technology to reduce interaction effects and also promote an increase in the solubility of the active ingredient. The membranes produced (15% m/v of Ecovio® in a solution of 85% chloroform: 15% dimethylformamide and with 5%, 10%, 20% and 30% m/m of drug) were prepared by scanning electron microscopy analyzes (SEM), infrared spectroscopy (FTIR), thermogravimetry (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), consistency analysis, conductivity, mechanical analysis, release and permeation study. The release profiles found were adjusted in different release kinetic models, with the Weibull model proving to be the most appropriate, as it is the most commonly used model for presenting drug release profiles in which a polymeric delivery matrix is used of pharmaceuticals. The best lamotrigine concentration obtained was 5%, due to greater release and permeation.