Impacto da exposição ocupacional aos agrotóxicos sobre os níveis de cortisol plasmáticos em mulheres portadoras de câncer de mama e seu significado clínico

Detalhes bibliográficos
Ano de defesa: 2023
Autor(a) principal: Jumes, Jaqueline Janaina lattes
Orientador(a): Panis, Carolina lattes
Banca de defesa: Panis, Carolina lattes, Follador, Franciele Ani Caovilla lattes, Velásquez, Leonardo Garcia lattes
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Estadual do Oeste do Paraná
Francisco Beltrão
Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Aplicadas à Saúde
Departamento: Centro de Ciências da Saúde
País: Brasil
Palavras-chave em Português:
Câncer de mama
Cortisol plasmático
Pesticidas
Disruptores endócrinos
Plasma cortisol;
Pesticides
Endocrine disruption
Palavras-chave em Inglês:
Breast cancer
Área do conhecimento CNPq:
CIÊNCIAS DA SAÚDE
Link de acesso: https://tede.unioeste.br/handle/tede/6717
Resumo: Pesticides have been pointed out as hormone disruptors, and may significantly affect the prognosis of hormone-dependent diseases as breast cancer (BC). Here we investigated the impact of occupational exposure to pesticides on the systemic levels of cortisol in female rural workers diagnosed with BC. Occupational exposure was determined by conducting interviews with a standardized questionnaire. Aiming to investigated cortisol deregulation, plasma samples (112 exposed and 77 unexposed) were collected out of cortisol physiological peak (at afternoon) and analyzed by method of cortisol immunoassay chemiluminescent, with paramagnetic particles for the determination quantitative analysis of cortisol levels in serum and plasma, measured in a automated. The results were categorized according to patients’ clinicopathological and exposure data. Women with BC exposed presented higher levels of cortisol concerning the unexposed. Higher cortisol levels were detected in BC exposed women carrying more aggressive disease (triple-negative BC), as in those with tumors over 2 cm, having lymph nodal metastasis, and under high-risk for disease recurrence and death. These findings support that the chronic occupational exposure to pesticides significantly deregulated cortisol circulating levels and can affect disease prognosis for BC patients.

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