Análise da atividade antitumoral, bactericida e interação com o dna do cloreto de c/s-tetraaminodiclororutênio (III)

• Ano de defesa: 2005
• Autor(a) principal: Menezes, Carla da Silva Rodrigues de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Genética e Bioquímica
• Palavras-chave em Português: Câncer; Multiplicação descontrolada das células; Diffley e Evan; Alterações oncogênicas; CNPQ::CIENCIAS BIOLOGICAS::GENETICA
• Link de acesso: https://repositorio.ufu.br/handle/123456789/26992; http://dx.doi.org/10.14393/ufu.di.2005.6

Cancer involves the loss of control of various processes, especially the uncontrolled multiplication of cells. The signaling pathway for cytokines and growth factors controls the replication process when it is needed throughout the body. Cancer cell proliferation occurs without the appropriate signal and the requirement for proliferation by other cells (Diffley and Evan, 1999). There are different types of cancer with different molecular causes. Oncogenic changes can be divided into two major groups: by acquisition (introduced by viral infection) and development (protooncogenes mutations) of oncogenes; or by genetic changes that contribute to cancer development due to the loss of functionality of tumor suppressor genes that protect cells against uncontrolled cell division (Diffley and Evan, 1999). The terms cancer, malignant neoplasia and malignant tumor are synonymous and are distinguished from benign tumors by their derifferentiation properties, invasive power and ability to metastasize, ie spread to other parts of the body (Lodish et al. , 2000). The neoplasms are separated into benign and malignant. The former have well-defined boundaries with adjacent tissue and do not produce secondary tumors distant from the main, ie, do not produce metastases like cancers. Evil