Amplitude da distribuição de volume (RDW) e da estabilidade osmótica (dX) de eritrócitos no diabetes mellitus tipo 2

Detalhes bibliográficos
Ano de defesa: 2021
Autor(a) principal: Knychala, Maria Aparecida
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Uberlândia
Brasil
Programa de Pós-graduação em Genética e Bioquímica
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
T2D
RDW
RBC
dX
Link de acesso: https://repositorio.ufu.br/handle/123456789/33344
http://doi.org/10.14393/ufu.te.2021.541
Resumo: This study aimed to investigate the relationship between red cell distribution width (RDW) and erythrocyte osmotic stability in non-diabetic and diabetic individuals in both sexes. The study sample (N=122) was constituted by 53 type 2 diabetics (T2D) and 69 non-diabetics (ND), being 21 and 22 men in each group, respectively. The osmotic stability of erythrocytes was obtained by the variation in saline concentration (dX) capable of determining hypoosmotic lysis. Higher RDW values and lower serum iron concentrations were found in the diabetic group when compared to the non-diabetic volunteers. In the group of diabetic women, RDW was positively correlated with the reticulocyte index, and both RDW and dX were negatively correlated with iron, hemoglobin, transferrin saturation index, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. In all the groups studied, RDW was positively correlated with dX, especially in the diabetic group, where the correlation was the strongest. RDW elevation in both women and men with type 2 diabetes mellitus was associated with decreased serum iron indicators. Furthermore, RDW has a similar meaning to dX, since small erythrocytes have less hemoglobin, resulting in both an increase of RDW and dX.