Amplitude da distribuição de volume (RDW) e da estabilidade osmótica (dX) de eritrócitos no diabetes mellitus tipo 2

• Ano de defesa: 2021
• Autor(a) principal: Knychala, Maria Aparecida
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Genética e Bioquímica
• Palavras-chave em Português: eritrócitos; red blood cells; anemia por deficiência de ferro; iron deficiency anemia; resistência osmótica eritrocitária; erythrocyte osmotic resistance; teste de fragilidade osmótica; osmotic fragility test; diabetes mellitus tipo 2; T2D; índices eritrocitários; erythrocyte indices; CHCM; RDW; RBC; dX; CNPQ::CIENCIAS DA SAUDE; Bioquímica; Diabetes; Eritrócitos
• Link de acesso: https://repositorio.ufu.br/handle/123456789/33344; http://doi.org/10.14393/ufu.te.2021.541

This study aimed to investigate the relationship between red cell distribution width (RDW) and erythrocyte osmotic stability in non-diabetic and diabetic individuals in both sexes. The study sample (N=122) was constituted by 53 type 2 diabetics (T2D) and 69 non-diabetics (ND), being 21 and 22 men in each group, respectively. The osmotic stability of erythrocytes was obtained by the variation in saline concentration (dX) capable of determining hypoosmotic lysis. Higher RDW values and lower serum iron concentrations were found in the diabetic group when compared to the non-diabetic volunteers. In the group of diabetic women, RDW was positively correlated with the reticulocyte index, and both RDW and dX were negatively correlated with iron, hemoglobin, transferrin saturation index, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. In all the groups studied, RDW was positively correlated with dX, especially in the diabetic group, where the correlation was the strongest. RDW elevation in both women and men with type 2 diabetes mellitus was associated with decreased serum iron indicators. Furthermore, RDW has a similar meaning to dX, since small erythrocytes have less hemoglobin, resulting in both an increase of RDW and dX.