Enxerto osteocondral alógeno, associado à inoculação de proteína morfogenética óssea no reparo do sulco troclear de coelhos

• Ano de defesa: 2011
• Autor(a) principal: Andrade, Lilian Vieira de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; BR; Programa de Pós-graduação em Ciências Veterinárias; Ciências Agrárias; UFU
• Palavras-chave em Português: Cartilagem; Glicerina; Osso; rhBMP-2; Ossos - Enxerto; Cartilage; Glycerin; Bone; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: https://repositorio.ufu.br/handle/123456789/13006

Twenty-four New Zealand rabbits, adult males were separated into two equal groups, control (GC) and treated (GT) with recombinant human bone morphogenetic protein 2. The groups were subdivided for evaluation at 45 (C1 and T1) and 90 days (C2 and T2). There was a lateral parapatellar incision in his left knee on the skin and joint capsule. The patella was displaced medially and a segment of the trochlear groove was removed. In CG and TG was filled with allograft osteochondral graft pre-served in glycerin at 98%. In rabbits the GT were administered 1 mg intra-articular bone morphogenetic protein 2 (rhBMP-2). There was adhesion of the joint capsule in four (33.3%) animals of the GT, and five (41.66%) of GC. Among the changes found in the cartilage graft was found, severe scaling in two animals (16.66%) followed by necrosis in four (33.3%), whereas in GT in three (25%) rabbits was found peeling, but without necrosis. It was found in eight (66.66%) rabbits GT hyaline cartilage growth in the process of ossification. The intra-articular inoculating of rhBMP-2 in the repair of the trochlear groove of rabbits with allogenic osteochondral allograft of rabbits pre-served in glycerin, satisfactory results in cartilage and bone repair after 45 and 90 days postoperatively.