Biossensores para detecção de Toxoplasma gondii

• Ano de defesa: 2018
• Autor(a) principal: Alves, Lívia Maria
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Genética e Bioquímica
• Palavras-chave em Português: Bioquímica; Toxoplasma gondii; Peptídeos; Biossensores; Peptídeo mimético; Poli (3-HBA); Poly (3-HBA); Mimetic peptide; CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA
• Link de acesso: https://repositorio.ufu.br/handle/123456789/24253; http://dx.doi.org/10.14393/ufu.te.2019.1202

Parasitic diseases represent challenges to human and animal health, especially in developing countries. Toxoplasma gondii is an intracellular parasite protozoan responsible for toxoplasmosis, a zoonosis of medical and veterinary importance throughout the world. An efficient diagnosis is very important for the prevention and treatment of these parasitic diseases. The development of biosensors to auxiliary in the diagnosis of diseases is a significant tool due to the advantages these devices present, such as low cost, sensitivity, selectivity and the possibility of miniaturization. Thus, this work aimed at the construction of two biosensors for the detection of Toxoplasma gondii through of the immobilization of a DNA-specific probe (genossensor) and a mimetic peptide (immunosensor) on graphite electrodes modified with poly (3-hydroxybenzoic) .