Uma noite com 6h de restrição de sono piora a performance em roedores submetidos ao treinamento resistido periodizado

• Ano de defesa: 2023
• Autor(a) principal: Nosé, Paulo Daubian Rubini dos Santos [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo
• Palavras-chave em Português: Sono; Restrição de sono; Exercício físico; Treinamento de força/resistido
• Link de acesso: https://repositorio.unifesp.br/handle/11600/70674

Introduction: Physical exercise is a powerful physiological and biomolecular stimulator capable of promoting various physiological responses. The physiological responses arising from physical exercise depend on the training load imposed between each session. Studies carried out in humans and animal models prove that sleep restriction has significant consequences on physical performance. Objective: The objective of the present work was to investigate the effects of sleep restriction on resistance training performance, quantifying biochemical and molecular variables. Methods: Thirty 60-day-old male Wistar rats were used, divided into four groups (Sedentary Control (SC; N = 5), Sedentary Sleep Restriction (SRS; N = 5), Trained Control (TC; N = 10), and Trained Sleep Restriction (SRT; N = 10)). The animals were subjected to an initial maximal strength test, followed by a periodized strength training protocol lasting six weeks. Subsequently, the animals were subjected to a period of six hours of sleep restriction, with reassessment of the maximum strength test. Results: The present research found an increase in the total body mass of all animals at the end of the six weeks of study. Six hours of sleep restriction was able to reduce the strength capacity of the TRS group by 18.4% compared to the TC group. There were no significant differences in glycogen values between the experimental groups for either the plantaris muscle or the soleus muscle. There was no significant difference in CLOCK protein concentrations in the plantar and soleus muscles. The work also demonstrated a significant difference in 15 metabolites from the anaerobic glycolysis pathway through metabolomic analysis. Conclusion We conclude that sleep restriction attenuates the performance of maximal strength capacity in trained animals, also demonstrating that the training process reduces the impact of sleep restriction on performance, altering several metabolites of the anaerobic glucose pathway.