Análise da relação entre polimorfismo do gene cyp17 e sintomas vasomotores em mulheres na pós-menopausa com terapia estrogênica

• Ano de defesa: 2011
• Autor(a) principal: Nogueira Júnior, Roberto Cesar [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: CYP17; Estrogênio; Fogachos; Polimorfismo; Polimorfismo Genético; Esteroide 17-alfa-Hidroxilase; Estrogênios
• Link de acesso: http://repositorio.unifesp.br/handle/11600/8909

To evaluate the influence of CYP17 polymorphism on menopausal symptoms after estrogen treatment. Design: A total of 130 women were recruited, but only 100 of these were selected according to inclusion and exclusion criteria, and they were treated with 0.3mg/day of conjugated equine estrogens. One year later the study was completed with 70 women. The analysis of the Kuppermann Menopausal Index (KMI) symptoms was made with information provided by the patients on daily diary cards. Blood samples were analyzed and the women were divided into two groups based on the CYP17, 5´ untranslated region: GA (wild-type homozygote and heterozygote) and GB (mutated homozygote). Results: The values of KMI were similar in both groups (GA = 31.11 ± 9.95 and GB= 30.39 ± 7.74) at baseline. The symptoms in both groups decreased after one year of treatment when compared to those at baseline. The improvement rate was approximately 27.09% and 32.18%, in GA and GB, respectively. The levels of estrogen after treatment were higher in both groups in comparison with the baseline values. The testosterone level rose in GB with the one-year treatment (0.48 ± 0.16) reaching a higher level than the GA level after treatment. The SHBG level showed a significant increase after the one-year treatment in GB surpassing both the baseline and the after treatment values of GA (p<0.01). Conclusion: Our data suggest CYP17 polymorphism did not influence the unopposed estrogen during the one-year treatment. The extra production of estrogen and androgen may have been countered by the elevation of SBHG.Key words: Polymorphism; CYP17; estrogen; hot flashes.