Validação de modelo de predição clínica para o diagnóstico de trombose venosa profunda dos membros inferiores

• Ano de defesa: 2001
• Autor(a) principal: De Souza, Edvaldo [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Diagnóstico; Embolia Pulmonar; Fatores de Risco; Síndrome Pós-Flebítica; Tromboembolia; Trombose Venosa
• Link de acesso: http://repositorio.unifesp.br/handle/11600/17618

Introduction: The deep vein thrombosis (DVT) has as serious complications lung embolism, important cause of mortality, and post-thrombosis syndrome ,the most frequent cause of chronic vein stasis of the lower limbs. The signs and clinical symptoms of DVT present a high rate of false-positive and false-negative, when compared to objective methods of diagnosis. The correct diagnosis of DVT, confirmed by phlebography or other non-invasive methods , permits the appropriate treatment with anticoagulants, reducing the incidence of lung embolism and minimizing chronic vein stasis. It also avoids the unnecessary exposure to the risks of anticoagulant therapy in the negative cases. With the indiscriminate use of subsidiary exams, the incidence of negative exams has increased, reducing the cost-benefit of these diagnostic methods. Philip S. Wells, of the University of Ottawa, Canada, in 1995 and 1997, proposed a method of clinical prediction for the diagnosis of DVT, and he concluded that it is possible to stratify groups accurately into high, moderate and low probability, rationalizing the use of supplementary diagnostic methods, method that needs validation in other centers, as suggested by the author himself. Objective: To test the hypothesis that the model of clinical prediction proposed by Wells is capable of stratifying the patients into groups of high, moderate and low probability of DVT of the lower limbs. Method: Prospective study, including 111 consecutive patients, 114 members, with signs and symptoms of DVT in the lower limbs. Of these, 99 carried out phlebography, resulting in 102 extremities studied. The patients were examined according to the order of their arrival in the hospital or by the request of intra-hospital evaluation of patients admitted for other reasons. A postgraduate student of vascular surgery, a second year resident of General Surgery, and a second year medical student, who had never had contact with patients with DVT, filled out forms based on the proposal by Wells, and would not have further contact with the examined patient. The phlebography were carried out by doctors that didn`t know about the forms and were just interpreted at the end of the study, by three other assisting doctors that didn`t know the identity of the patients and had not participated in the treatment or previous evaluation. Results: In 65 (63,7%) of the 102 lower limbs the presence of DVT was proven by phlebography. The clinical model of Wells demonstrated a prevalence of DVT of 85,5% in the category of high probability, 50% in the group of moderate probability and 25% in the category of low probability. The location of DVT was proximal, starting from the popliteal vein, by 80,6%, 25% and 12,5%, while it was located exclusively in the veins of the calf by 4,8%, 25,0% and 12,5%, in the high, moderate and low probability groups, respectively. The coefficient of reproducibility of Cronbach among the postgraduate, the resident and the student was 86,3%. Conclusion: The model of clinical prediction of DVT proposed by Wells allows adequate identification of patients with high probability and with DVT proximal. However, the method is unsatisfactory for the identification of DVT in the patients allocated in the moderate and low probability groups.