Uso de matrizes de rins descelularizadas e repopulados com células tronco estromais mesenquimais da medula óssea

• Ano de defesa: 2017
• Autor(a) principal: Cruz, Edgar Ferreira da [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Regeneration; Extracellular matrix; Renal insufficiency, chronic; Tissue engineering; Regeneração; Matriz extracelular; Doença renal crônica; Engenharia de tecidos
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5747043; http://repositorio.unifesp.br/handle/11600/50627

Chronic kidney disease is a pandemic health problem worldwide. The number of people affected by this disease grows exponentially. Studies shows the bioengineered organs associated to stem cells as a possibility of new strategies of development to treatment of chronic kidney disease. In this research, we developed a platform of understand steps of regeneration kidney tissues, using extracellular matrix scaffold from different species with mesenchymal stem cell from bone marrow and umbilical cord human stem cells. Our results showed the decellularization process, the repopulation of the ECM scaffold in differents time points of tissue culture and some biological steps of this “re” construction