Avaliação da flora bacteriana conjuntival em pacientes com Síndrome de Stevens-Johnson

• Ano de defesa: 2019
• Autor(a) principal: Frizon, Luciana [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Conjunctival Flora; Microbial Sensitivity Tests; Stevens-Johnson Syndrome.; Flora Conjuntival; Testes De Sensibilidade Microbiana; Síndrome De Stevens-Johnson
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8071449; https://repositorio.unifesp.br/handle/11600/59680

Objective: To determine the conjunctival bacterial flora present in patients with Stevens-Johnson Syndrome (SJS). Methods: A prospective study of the conjunctival bacterial flora was performed in 41 eyes of 22 patients with SJS. The information gathered included the patient’s sex and age, the duration of disease, cause of SJS, and treatments. Scrapings of the inferior conjunctival fornix were performed in both eyes. Fourteen days before scraping, the patients were asked to interrupt all topical medication and start using 0.5% nonpreserved methylcellulose. The microbiological evaluation included microorganism identification and determination of antibiotic sensitivity. Results: Of 22 patients (41 eyes), 14 (64%) were females and eight (36%) were males. The mean age was 33.2 years, and mean duration of disease was 15.6 years. Visual acuity ranged from light perception to 20/25 (1.57 logMar). The treatment received by most patients consisted of tear substitutes, topical antibiotics and contact lenses. Bacterial identification was positive in 39 eyes (95%) and negative in two eyes (5%). Gram-positive cocci accounted for 55.5% of the microorganisms, whereas grampositive bacilli and gram-negative bacilli accounted for 19% and 25.5%, respectively. Half of the patients (54%) had multiple bacteria species in their flora, and only one bacterial species was identified in the other half. Resistant bacteria were isolated from four eyes. The antibiotic sensitivity results for the Streptococcus group showed the lowest sensitivity and highest microbial resistance identified. Conclusion: Patients with Stevens-Johnson Syndrome have a diverse conjunctival flora that includes many pathogenic species.