Fatores orexígenos e anorexígenos, composição corporal e taxa metabólica de repouso em adolescentes obesos: efeitos do tratamento multidisciplinar de longo prazo

• Ano de defesa: 2011
• Autor(a) principal: Comparoni, Aniella [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Adolescente obeso; Taxa metabólica de repouso; Terapia multidisciplinar; Fatores orexígenos e anorexígenos; Depressores do apetite; Obesidade; Adolescente; Multidisciplinary therapy; Obese adolescent; Resting metabolic rate; Orexigenic and anorexigenic factors; Appetite depressants; Obesity; Adolescent
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9645

Background/Aims: anorexigenic and orexigenic factors and resting metabolic rate (RMR) play an important role in the energy balance and they are directly related to obesity. In this way, it was verified the effects of long-term multidisciplinary therapy on orexigenic and anorexigenic factors and resting metabolic rate in obese adolescents. Methods: Twenty obese adolescents (11 girls and 9 boys) aged between 14 and 19 years, BMI > 95th percentile of CDC, were submitted to intensive long-term multidisciplinary therapy during 12 months. Orexigenic and anorexigenic factors concentrations were measured by a radioimmunoassay (RIA) kit. RMR was measured by indirect calorimetry. Body composition was measured by pletismography, and visceral and subcutaneous fat were analyzed by ultrassonography. Results: After one year of multidisciplinary therapy, the obese adolescents presented a significant decrease in body mass (p<0.001), BMI (p<0.001), fat mass (kg and %), lean mass (kg), subcutaneous and visceral fat. The group did not decrease significantly in RMR and RMR/FFM. The anorexigenic factors (leptin and alpha- MSH concentrations) decreased significantly. The orexigenic neuropeptide (MCH) increased by the end of the multidisciplinary therapy. Conclusion: Our investigation demonstrated that long-term multidisciplinary therapy was effective to improve body composition, anorexigenic and orexigenic factors contributing to obesity control.