Detalhes bibliográficos
Ano de defesa: |
2022 |
Autor(a) principal: |
Teixeira, Igor de Lima e [UNIFESP] |
Orientador(a): |
Não Informado pela instituição |
Banca de defesa: |
Não Informado pela instituição |
Tipo de documento: |
Dissertação
|
Tipo de acesso: |
Acesso aberto |
Idioma: |
eng |
Instituição de defesa: |
Universidade Federal de São Paulo
|
Programa de Pós-Graduação: |
Não Informado pela instituição
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: |
|
Link de acesso: |
https://repositorio.unifesp.br/handle/11600/67373
|
Resumo: |
Introduction: Many cognitive screening tests have been investigated for the diagnosis of Parkinson's Disease Dementia (PDD), due to its prevalence and its interference in the evolution of the disease, in the quality of life and in the treatment response of the patients with Parkinson’s Disease (PD). Therefore, more effective and faster cognitive screening tests are needed. Objective: To evaluate the usefulness of the NINDS-CSN 5 Minutes Protocol Assessment (NC5MPA) in PD patients as screening test for the detection of PDD, as well as to test if the association with the Cube Drawing Test (CDT) can increase the test accuracy. Methods: A total of 98 patients with PD were evaluated using the NC5MPA, combined with the CDT, Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). These patients were also evaluated for mild cognitive impairment (MCI) and dementia by the Clinical Dementia Rating Scale (CDR). Results: In a bivariate analysis of the 3 tests, there was a good correlation (with p value < 0.000) between the test scores and PDD, but the results of the 3 tests for MCI was > 0.05. The NC5MPA test has had sensitivity of 78.5%, specificity of 85.7%, accuracy of 82.6%, positive predictive value (PPV) of 80.4% and negative predictive value (NPV) of 84.2%, in addition to demonstrate an average performance time of 3.2 minutes (3.08 - 3.31). The association with the CDT has led to a little significant increase in sensitivity and has showed a decrease in specificity and accuracy, besides increase the test performance time. In assessing the interference of education level, the results were influenced by the small sample size of the 5 to 8 years of education group. Conclusion: The NC5MPA test has proven up to be a good screening test for PDD, being even faster and easier to perform, but more tests with larger populations are necessary to assess the accuracy of this test for MCI and to assess if there is interference of education level in the test accuracy. |