Imuno Expressão de proteínas regulatórias da apoptose, p53, Bcl-2 e Bax em Ulcerações Aftosas Recorrentes

• Ano de defesa: 2011
• Autor(a) principal: Rodrigues, Joao Flavio Nishihara Pinto [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Apoptose; Bax; Imunohistoquímica; Ulceração aftosa recorrente; Estomatite aftosa; Apoptosis; Recurrent aphthous ulceration
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9723

Recurrent aphthous ulceration (RAU) is considered to be a chronic inflammatory disease of unknown pathogenesis. Apoptosis may represent an important event in the control of inflammation.The aim of this study was to investigate apoptosis process in RAU by means of immunohistochemistry. We studied the expression and location of proteins related with intrinsic pathway of apoptosis p53, bcl-2 and bax in ulcerated lesions clinically diagnosed as RAU (n = 12) and to compare it with that of oral clinically normal mucosa (7) and of other inflammatory chronic disease such as oral fibrous inflammatory hyperplasia (FIH; n = 18). Significant statistically differences (p<0.05) in p53 expression were noticed to RAU when compared to normal mucosa. Bcl-2 and bax did not show remarkable differences between groups. Taken together, the data suggest that RAU induces apoptosis as a result of p53 upregulation. This protein might be related with the aetiopathogenesis of the ulcerated oral lesions.