Avaliação do efeito da fenitoína (5,5-difenil-2-4- imidazolidione, sódio) na cicatrização cutânea da excisão de nevos melanocíticos na face e no dorso do tórax

• Ano de defesa: 2009
• Autor(a) principal: Pereira, Carlos Augusto Zanardini [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Cicatrização de feridas.; Cicatrização; Fenitoína; Farmacologia; Melanomas e nevos; Wound healing.; Phenytoin; Pharmacology; Nevi and melanomas
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9078

This study aims to evaluate the effect of topical use of phenytoin in healing of skin wounds. A systemic therapy with phenytoin have anticonvulsant activity, and the topical use action is to accelerate the healing of skin wounds. This study evaluated 100 patients each with 2 wounds resulting from excision of lesions of melanocytic nevi, 50 patients with lesions on the face and 50 whith back injuries in the chest, total of 200 lesions excised with punch modified. During treatment the patient received phenytoin to 0.5% in the cream and cream base (control), to make the dressing daily. The follow up of patients was carried out from 7, 14, 21 and 60 days, where the following parameters were evaluated: bleeding, exudate, erythema at the edge of the wound, infection, presence of hypertrophic granulation tissue, healing time, intensity of epithelialization, the wound area, the shape and area of the scar, possible adverse reactions and cosmetic outcome. The patients were compared in age, weight, height, phototype, histological type of lesion. The phenytoin showed better therapeutic and cosmetic results compared with the cream base (control). The phenytoin is a drug of low cost, which accelerates the healing of skin wounds.