Concentração de colágeno na pele facial de mulheres na pós-menopausa após tratamento com estradiol e genisteína tópicos: um estudo randomizado duplo cego

• Ano de defesa: 2016
• Autor(a) principal: Sampaio, Lidia Lima Aragao [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: collagen; estrogens; phytoestrogens; genistein; menopause; hormone replacement therapy; colágeno; estrogênios; fitoestrógenos; genisteína; menopausa; terapia de reposição hormonal
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=3688607; https://repositorio.unifesp.br/handle/11600/46506

Objective: To compare the known effects of estrogen with genistein on the facial skin collagen of postmenopausal women without hormone therapy. Methods: This is a clinical, cross over trial with randomized and blinded convenience sample with estrogen and isoflavones, which 30 volunteer postmenopausal women were recruited to quantify facial collagen concentration before and after topical use of estrogen and isoflavones for 24 weeks. Results: The amount of both types I and III collagen increased at the end of both treatments, but estrogen was superior to the phytoestrogen, with statistical significance. Conclusion: Treatment with topical estrogen is superior to phytoestrogen, but both showed an increase in facial skin collagen, with statistical significance. What is not yet clear is whether prolonged topical use of such substances can cause systemic effects, thus, more research is needed to clarify this question.