Estudos visando a síntese total da Isodolastatina H

• Ano de defesa: 2008
• Autor(a) principal: Guarezemini, Alexandre Sardelli [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Organotrifluoroborates; Beta-hydroxy-gama-aminoacids; Organic synthesis; Isodolastatin H; Beta-hidroxi-gama-aminoácidos; Organotrifluoroboratos; Síntese orgânica; Isodolastatina H
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9606

This dissertation, are described the study towards to total synthesis of isodolastatin H, a natural peptide ester of dolastatin family with great citotoxicity activity. The main focus in this synthesis, is the construction of gama-aminoacid units Dil and Dap, obtained via addition reaction of crotyl and allyltrifluoroborate salts with L -prolinal and L-valinal, respectively. The junction of fragments was subsequently made from esterification and amidation reaction.