Prevalência e correlações clínicas da infecção pelo herpesvírus humano tipo 8 em indivíduos recém-infectados pelo HIV

• Ano de defesa: 2009
• Autor(a) principal: Batista, Mariana Dias [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Fatores de risco; Co-infecção; Doenças sexualmente transmissíveis; HHV-8; HIV-1; Co-infection; Risk factors; Sexually transmitted diseases
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9968

Background: Human herpesvirus 8 (HHV-8) is the etiological agent for Kaposi’s sarcoma, which occurs especially in HIV-infected subjects. HHV-8 infection and its clinical correlates have not been well characterized in recently HIV-1-infected individuals. Methods: We assessed the HHV-8 seroprevalence, clinical correlates, and incidence after one year of follow-up in a cohort of 228 recently HIV-1-infected individuals using indirect immunofluorescence assay. Results: The prevalence of HHV-8 infection at the time of cohort enrollment was 25.9% (59/228). In the univariate model, there were significant associations with male gender (p=0.05), black ethnicity (p=0.021), men who have sex with men (MSM) practice (p=0.023), and previous hepatitis B virus (p=0.009) and syphilis (p=0.034) infections. In the multivariate model we could still demonstrate association with MSM, hepatitis B, and black ethnicity. No differences in mean CD4+ cell counts or HIV viral load according to HHV-8 status were found. In terms of incidence, there were 23/127 (18.1%) seroconversions in the cohort after one year. Conclusions: HHV-8 is highly prevalent among recently HIV-1-infected subjects. Correlations with other sexually transmitted infections suggest common transmission routes.