Manual Para Diagnostico, Conduta E Notificação Do Linfoma Anaplasico De Grandes Células Associado Ao Implante Mamário De Silicone Texturizado

• Ano de defesa: 2018
• Autor(a) principal: Abelha, Ricardo [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Anaplastic Large Cell Lymphoma; Breast Implant; Breast Cancer; Linfoma Anaplásico De Grandes Células; Implante De Mama; Cancer De Mama
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=6516881; https://repositorio.unifesp.br/handle/11600/52628

Introduction: The increasing number of women with BIA-ALCL is surprising plastic surgeons around the World. Anaplastic Lymphoma of Large Cells Associated to Breast Implants (BIA-ALCL) was recently included in the category of lymphoid neoplasms by the World Health Organization, calling attention to the matter. Brazil ranks second in breast implant surgeries, but less than ten cases of BIA-ALCL were reported in recent years, in contrast to the United States, which confirmed 230 cases only in 2018. Objective: To develop a manual to systematize the conducts referring to the first contact of the plastic surgeon with the suspected cases of Anaplastic Large Cell Lymphoma Associated with the Silicone Breast Implant, unifying the practice of the professionals in the accomplishment of the correct diagnosis and stages following the identification of the disease. Methods: Manual developing studies. It was approved by the CEP of the UNIFESP CAAE: 92274218.4.0000.5505. An anteriority search was carried out and there were an explanatory video on the subject for health professionals and patients, an online and printed informative pamphlet for patients, a pamphlet containing the main questions and answers about the subject, but no materials or documents were found that addressed the subject of this study in the form of a manual. For the development of the content the bibliographic databases and search sites Cochrane, Scielo, LILACS, and Pubmed were consulted, articles were selected in Portuguese and English from 2008 to 2018, with the exception of the first case report of this lymphoma published in 1997. The descriptors in question were: Large Cell Anaplastic Lymphoma, Breast, Breast Implant and Lymphoma. Then the text, illustrations and diagram were elaborated. After its elaboration, the manual was evaluated by specialists by the CVI (Content Validation Index). Results: The completed manual has eighteen pages and nine chapters with the following topics: Introduction, Diagnosis, Staging, Management, Treatment, Notification, Final Considerations, Flowchart and Bibliography. Conclusion: A manual was developed and validated for the diagnosis, management and reporting of Anaplastic Large Cell Lymphoma Associated with Texturized Silicone Breast Implants.