Repercussões da interposição ileal isolada em ratos com dismetabolismo glicídico induzido por dieta

• Ano de defesa: 2017
• Autor(a) principal: Leal, Lucas Pedroso Fernandes Ferreira [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Bariatric surgery; Diabetes mellitus, Type 2; Surgery; Ileal interposition; Ileal transposition; Glucagon-like peptide-1 (Glp-1); Incretins; Insulin resistance; Diet; High fat; Animal experimentation; Rats; Wistar; Ileum; Pancreas; Pathology; Cirurgia bariátrica; Diabetes mellitus tipo 2; Cirurgia; Interposição ileal; Transposição ileal; Peptídeo semelhante ao glucagon 1 (Glp-1); Incretinas; Resistência à insulina; Dieta hiperlipídica; Experimentação animal; Ratos Wistar; Íleo; Pâncreas; Histopatologia
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5032182; https://repositorio.unifesp.br/handle/11600/50718

INTRODUCTION: The clinical management of type 2 diabetes mellitus (T2DM) is complex and permanent. In this moment, it is necessary a surgical procedure considered effective for the treatment of this disease among individuals with body mass index above morbid obesity. The isolated ileal transposition (III) could become an alternative therapy in selected non-obese diabetic patients. There are no reports of III performed in wistar rats in an experimental model of diet-induced disglycemia without genetic or drug influences, nor its pancreas morphology evaluation. OBJECTIVE: This study aims to contribute to the treatment of T2DM, evaluating the physiological effects of III on glucose metabolism and investigating histological changes of the pancreas in an experimental model of diet-induced disglycemia. METHODS: Seventy two 12-week-old male Wistar rats were distributed into four groups - ileal transposition, sham-operated, diabetic controls and non-diabetic controls (NG). The NG group received usual rat feeding while the other groups received hypercaloric-hyperlipidic diets. III was carried out in obese disglycemic rats at the 30-week. All groups maintained their diets untill the 48-week. Glucose tolerance, insulin resistance, food-intake, body weight, adiposity, serum substances and pancreas morphology were evaluated. RESULTS: After a postoperative period of 18 weeks, the III improved glucose tolerance and insulin sensitivity in diet-induced disglycemic rats. III did not induced weight loss or food intake decrease, and did not affected fat mass. It did not promoted morphological pancreatic alterations. CONCLUSIONS: In rats with diet-induced disglycemia, III promotes beneficial changes in glucose metabolism and does not modify the morphology of the endocrine pancreas.