Fatores de risco genéticos e psicossociais associados á idisfunção temporomandibular

• Ano de defesa: 2018
• Autor(a) principal: Tagliavini, Camila Leite Quaglio [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Temporomandibular joint disorders; Syndrome of temporomandibular joint dysfunction; Genetic polymorphism; Single nucleotide polymorphism; Psychosocial impact; Transtornos da articulação temporomandibular; Síndrome da disfunção da articulação temporomandibular; Polimorfismo genético; Polimorfismo de nucleotídeo único; Impacto psicossocial
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=7022251; https://repositorio.unifesp.br/handle/11600/52331

Objectives: To identify biopsychosocial risk factors for myofascial Temporomandibular Disorders in a Brazilian sample. The biological factors encompassed 15 polimorphisms of CAMK4, CHRM2, ESR1, GRK5, IFRD1, MC1R, MTRR, NR3C1, OPRM1 and TPH1 genes, and the psychosocial factors encompassed ‘depression symptoms’, ‘somatization symptoms’ and ‘pain intensity and disability’. Methods: The sample consisted of 679 participants, 272 with myofascial Temporomandibular Disorders and 407 controls. Axis I of Research Diagnostic Criteria for Temporomandibular Disorders was used to classify the participants into the groups and axis II was used to classify the psychosocial factors. Genotyping analysis used TaqMan® Low Density Array. Binary logistic regression models were performed in order to assess the influence of the genetic factor on the presence of Temporomandibular Disorders and pain duration, the influence of psychosocial factors on the presence of Temporomandibular Disorders, the influence of ‘Depression and Somatization symptoms’ on the presence of ‘Pain intensity and disability’ and the influence of genetic factor on the presence of psychosocial factors. Results: After Bonferroni correction, no polimorphisms studied were associated with myofascial Temporomandibular Disorders. ‘depression symptoms’, ’somatization symptoms’ and ‘pain intensity and disability’ were associated with myofascial Temporomandibular Disorders. Female group had more ‘depression symptoms’, ’somatization symptoms’ and ‘pain intensity and disability’ than male group. Conclusion: The polimorphisms studied can not be consider genetic risk factors for myofascial Temporomandibular Disorder. The sample with myofascial Temporomandibular Disorders were more emotionally debilitated than the sample without this disorder; they presented more ‘Depression and Somatization symptoms’. Females with myofascial Temporomandibular Disorders were more emotionally debilitated than males with myofascial Temporomandibular Disorders in all psychosocial factors.