Análise do padrão articulatório da tarefa de fluência verbal frutas no comprometimento cognitivo leve, na demência de Alzheimer leve e moderado

• Ano de defesa: 2017
• Autor(a) principal: Giacominelli, Carla [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Alzheimer disease; Neuropsychology; Language; Formação; Narrativa; Experiência; Cartografia; Perspectiva inversa; Doença de Alzheimer; Neuropsicologia; Linguagem
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5454029; http://repositorio.unifesp.br/handle/11600/50036

The semantic verbal fluency task as a neuropsychological assessment, is widely used in the clinical practice of Alzheimer's Disease (AD) and involves the subject generate during 60s to generate the highest number of words belonging to a specific semantic category. Verbal fluency animals and verbal fluency fruits (VFf) have previously been described to be similarly effective in discriminating normal participants from subjects with AD. Both tasks were less accurate in discriminating AD-stages for unknown reasons. Based on semantic clustering scores in verbal fluency animals, a literacy depending pattern has been revealed across cultures; however, no previous analysis has been performed for VFf. The aim of this study is to investigate whether the task of verbal fluency fruit is useful for discriminating controls, Mild Cognitive Impairment (MCI), Mild Alzheimer Disease (MAD) and Moderate Alzheimer Disease(ModAD) and to determine task’s specificities and sensibilities at various stages of the AD. Methods: Three-hundred-fourteen native Brazilian Portuguese speakers were divided in four groups: Control Group (CG) and Mild Cognitive Impairment (MCI), Mild Alzheimer’s Disease (MAD) and Moderate Alzheimer’s Disease (ModAD) groups. A quantitative total score and a qualitative, clusters analysis, were conducted for VFf and were compared to other cognitive tasks. As no semantic setting was found, a non-arbitrary classification of fruits based on sub categorical items, according to the articulatory point of International Phonetic Alphabetic (2015) was performed. The words were grouped as follows: 1) bilabial, 2) velars, 3) open vowels, 4) closed vowels, 5) lateral dental/ alveolar, 6) dental /alveolar, and 7) labio- dentals. Results: Clustering strategies in the AD groups differed from those of the CG. Clustering revealed differences beyond groups depending on which articulatory point was emitted. MCI had a 73% lower chance of attaining an NV than did the CG and with AD groups presented odds ratios of using the /k/, /g/ velars feature 85% lower than those of the CG. Participants who used bilabials had 2.04 times higher total scores than those who did not. Younger subjects had a higher probability to perform better on the task. Participants with ≥ 9 years of education had a higher probability of higher performance with respect to the total score. Conclusion: Articulatory deterioration occurred in AD since the early stages. VFf seems to be a suitable task since MCI evaluation.