Efeitos do óleo de peixe sobre indicadores indiretos de lesão e morfologia das fibras musculares em ratos wistar submetidos a treinamento resistido

Detalhes bibliográficos
Ano de defesa: 2018
Autor(a) principal: Coqueiro, Daniel Pereira [UNIFESP]
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=7150181
https://repositorio.unifesp.br/handle/11600/52355
Resumo: Introduction: Fish oil rich in omega-3 polyunsaturated fatty acids (PUFA/n3) has been studied for the purpose of reducing levels of inflammation, which are increased under disease conditions or tissue lesions. Objective: To evaluate the effects of fish oil intake on muscle injuries induced by resistance exercise (RE). Methods: Fifty-Six Wistar rats were initially divided into three groups. Control group (Cont), composed of eight animals that did not receive fish oil and did not make RE; Resistance Exercise Group (Ex) composed of 24 animals that performed RE and did not receive fish oil; and Resistance Exercise group and fish oil (ExO) composed of 24 animals that performed RE and received fish oil. The RE was performed in a tank and consisted of vertical jumps from the bottom of the tank to the surface of the water. For the protocol, an additional load was fixed to the thorax of the animals. The animals performed 10 vertical jumps repeated 4 times (series) with 60s intervals between sets, three times a week for 8 weeks. The animals of the EXO Group received 2g/kg/day of fish oil. At the end of the last RE session, the animals receiving fish oil and those not receiving the fish oil were subdivided according to the time of blood collection and withdrawal of the gastrocnemius muscle (12, 24 and 48 hours). Results: The indicators of muscle injury Creatine Kinase (CK) and lactic dehydrogenase (DHL) were lower in the groups that ingested fish oil and belonged to time periods 12, 24, 48 h post RE. The values of Protein C reactive (PCR) and Myoglobin (Mb) were respectively lower in the group analyzed in the period 24 and 12h post RE and that received fish oil. Animals that used fish oil thromped statistically more favorably to dissociation of muscle fibers, presence of inflammatory infiltrate and necrosis.Conclusion: The physical exercise model produced alterations in the indirect serum markers of muscle lesion and morphological alterations, and the fish oil intake decreased the serum levels of these indicators and mitigated the morphological alterations in muscle tissue.